{"id":"W3131081717","doi":"10.3390/cells10071792","title":"Unveiling the Roles of Low-Density Lipoprotein Receptor-Related Protein 6 in Intestinal Homeostasis, Regeneration and Oncogenesis","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Wnt signaling pathway; LRP6; Biology; Stem cell; Frizzled; Carcinogenesis; Cell biology; LRP5; Azoxymethane; Cell growth; Intestinal epithelium; Cellular differentiation; Cancer research; Signal transduction; Epithelium; Cancer; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001837084,0.0002679292,0.0001933311,0.0002694209,0.0001094771,0.0004211764,0.0002507145,0.0003539255,0.000631783],"category_scores_gemma":[0.00008633731,0.0001277364,0.0002033572,0.0001358784,0.0002980786,0.0005744116,0.0002460829,0.0008480892,0.0003287108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001821492,"about_ca_system_score_gemma":0.0002188526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001721584,"about_ca_topic_score_gemma":0.0003070992,"domain_scores_codex":[0.9999114,0.00001457989,0.000008201543,0.00001590689,0.00002755329,0.00002227179],"domain_scores_gemma":[0.9999273,0.000006793443,0.00002644736,0.000006169376,0.000009941444,0.00002338151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005665761,0.00005894255,0.001191268,0.0003894537,0.00002026019,0.0004925579,0.00004750787,0.0002062247,0.9801568,0.001946888,0.0002746354,0.01464903],"study_design_scores_gemma":[0.0001725273,0.001692117,0.03927834,0.0001649748,0.0002691927,0.004585404,0.0005988722,0.005813218,0.8652606,0.003093941,0.07902429,0.00004654008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9140788,0.07196944,0.007670051,0.002176678,0.000147614,0.00002886982,0.0003240806,0.0001379736,0.003466471],"genre_scores_gemma":[0.9582776,0.03454917,0.003067517,0.0004165776,0.00009742188,0.0000234342,0.0003419777,0.00002158662,0.003204707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000631783,"threshold_uncertainty_score":0.002113521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006387831430981465,"score_gpt":0.2218506450127737,"score_spread":0.2154628135817923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}