{"id":"W3131081717","doi":"10.3390/cells10071792","title":"Unveiling the Roles of Low-Density Lipoprotein Receptor-Related Protein 6 in Intestinal Homeostasis, Regeneration and Oncogenesis","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Wnt signaling pathway; LRP6; Biology; Stem cell; Frizzled; Carcinogenesis; Cell biology; LRP5; Azoxymethane; Cell growth; Intestinal epithelium; Cellular differentiation; Cancer research; Signal transduction; Epithelium; Cancer; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003314161,0.00009846539,0.0001400987,0.00002740205,0.00006158446,0.0000121622,0.0000636116,0.0001565134,0.00001225782],"category_scores_gemma":[0.00007174417,0.00007548763,0.00003722038,0.0001465524,0.00007342704,0.000002789019,0.00006261258,0.0001009747,0.000006441805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001488132,"about_ca_system_score_gemma":0.000151357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007445268,"about_ca_topic_score_gemma":0.0003040059,"domain_scores_codex":[0.9990726,0.0001987742,0.000262912,0.0002433647,0.00008465899,0.0001377025],"domain_scores_gemma":[0.9995143,0.0000140608,0.0001089825,0.0001951618,0.0001251788,0.00004232513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002959303,0.00004710841,0.0004751056,0.00008501209,0.00001729417,0.000005116631,0.0001555145,0.00007789335,0.992312,0.00007239692,0.00008491825,0.006638117],"study_design_scores_gemma":[0.0002919689,0.00008659693,0.001257063,0.0001957071,0.000006950387,0.0000122557,0.0003174071,0.00005546706,0.9967972,0.00003508044,0.0008568596,0.00008742541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935578,0.005297026,0.0001222891,0.0002534837,0.00008221703,0.0002913942,0.000005793401,0.000005260335,0.0003847301],"genre_scores_gemma":[0.9982945,0.0005011937,0.0003558035,0.00003474656,0.00005194285,0.00001337502,0.00004724,0.00001141521,0.0006898174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006550692,"threshold_uncertainty_score":0.3078296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006387831430981465,"score_gpt":0.2218506450127737,"score_spread":0.2154628135817923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}