{"id":"W3131121535","doi":"10.1016/j.celrep.2021.108769","title":"Chromatin dysregulation associated with NSD1 mutation in head and neck squamous cell carcinoma","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health","keywords":"Chromatin; Biology; Epigenomics; Carcinogenesis; Histone; Genetics; Histone methyltransferase; Gene; Mutation; DNA methylation; Polycomb-group proteins; Cancer research; Gene expression; Repressor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001659563,0.0001039694,0.0001088585,0.00003257528,0.00006294002,0.00002383136,0.00002084294,0.0001267767,0.00000931897],"category_scores_gemma":[0.00008649684,0.0001052802,0.00002372419,0.0001118029,0.00002129848,0.000004419912,0.00005380277,0.00005056005,5.39915e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002281418,"about_ca_system_score_gemma":0.00008843966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005330223,"about_ca_topic_score_gemma":0.0003691837,"domain_scores_codex":[0.9991122,0.00005816556,0.0002460291,0.000318894,0.0001259239,0.0001387215],"domain_scores_gemma":[0.9994459,0.0000144316,0.0001774771,0.0002071401,0.0001059768,0.00004910467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001420661,0.0001058379,0.2893293,0.00003025039,0.000003368915,0.0003282482,0.0001591165,0.0008548729,0.708465,0.000001806916,0.00002852867,0.0006793672],"study_design_scores_gemma":[0.0004413308,0.0001357051,0.4023127,0.000008802363,0.0000101594,0.00002385824,0.00003208497,0.0002518219,0.5963805,0.000113465,0.0001833379,0.0001062192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944587,0.001859824,0.0003272371,0.0000216577,0.00006163334,0.0001299097,0.000001700261,0.00000710239,0.003132212],"genre_scores_gemma":[0.9981583,0.00002281762,0.0004455076,0.0000248735,0.00003707209,0.000009178606,0.0004372188,0.00001769303,0.0008473588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1129834,"threshold_uncertainty_score":0.4293203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007412987792507928,"score_gpt":0.2221794686523974,"score_spread":0.2147664808598895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}