{"id":"W3131121535","doi":"10.1016/j.celrep.2021.108769","title":"Chromatin dysregulation associated with NSD1 mutation in head and neck squamous cell carcinoma","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health","keywords":"Chromatin; Biology; Epigenomics; Carcinogenesis; Histone; Genetics; Histone methyltransferase; Gene; Mutation; DNA methylation; Polycomb-group proteins; Cancer research; Gene expression; Repressor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001134689,0.0001667442,0.0002290134,0.0004847756,0.0001974298,0.0001824957,0.0001396803,0.0002510776,0.001383418],"category_scores_gemma":[0.0001633656,0.0001020217,0.0002110603,0.000304839,0.0002982256,0.00008692176,0.0002219562,0.0001949244,0.0001760498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003391115,"about_ca_system_score_gemma":0.0001986043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001655768,"about_ca_topic_score_gemma":0.002707255,"domain_scores_codex":[0.9999108,0.00001104883,0.000009220903,0.00002141117,0.00003451699,0.00001294414],"domain_scores_gemma":[0.9998966,0.00002091536,0.00003735096,0.00001096618,0.00001171607,0.00002250706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003389765,0.00002842197,0.03385073,0.00007535968,0.00003555698,0.002934253,0.00007020035,0.0002721553,0.9575937,0.0001279787,0.0001439991,0.004528721],"study_design_scores_gemma":[0.0000323122,0.0002259388,0.5786934,0.00001317221,0.00009822767,0.01394929,0.0002364163,0.002206216,0.4010609,0.0003407708,0.003124306,0.00001909187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975258,0.0007593194,0.0006682387,0.00004565062,0.0000108089,0.00001853332,0.000302399,0.00003411843,0.0006352497],"genre_scores_gemma":[0.9988434,0.0002729094,0.0003924015,0.00002762977,0.000002241941,0.00000774013,0.0001797373,0.00000460616,0.0002692051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001655768,"threshold_uncertainty_score":0.004628003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007412987792507928,"score_gpt":0.2221794686523974,"score_spread":0.2147664808598895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}