{"id":"W3131128826","doi":"10.1186/s13024-021-00422-x","title":"Prion protein oligomers cause neuronal cytoskeletal damage in rapidly progressive Alzheimer’s disease","year":2021,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Helmholtz-Alberta Initiative; Deutsches Zentrum für Neurodegenerative Erkrankungen; Bundesministerium für Bildung und Forschung","keywords":"Cell biology; Immunoprecipitation; Cytoskeleton; Biology; Proteomics; Actin cytoskeleton; Tubulin; Neuroscience; Chemistry; Microtubule; Biochemistry; Cell; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001777721,0.0004748309,0.0001985722,0.0005692054,0.0002063855,0.0002157446,0.0001147049,0.0002855659,0.0007774286],"category_scores_gemma":[0.0001718856,0.000154942,0.0001656138,0.0002250071,0.0002165034,0.0001743419,0.000235208,0.0003133893,0.0003898818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001255944,"about_ca_system_score_gemma":0.00008084644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002332132,"about_ca_topic_score_gemma":0.0002988825,"domain_scores_codex":[0.9999186,0.00001244069,0.00001119921,0.00001863171,0.00002607754,0.0000130686],"domain_scores_gemma":[0.9998492,0.00001566198,0.00006999656,0.000009741698,0.0000262365,0.00002923947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006087667,0.0001116302,0.01481792,0.0001542204,0.00005158946,0.003461689,0.0001114659,0.00009961584,0.9768586,0.0001200229,0.0002377888,0.003366626],"study_design_scores_gemma":[0.0001065547,0.001645959,0.637036,0.00006925664,0.0002506615,0.03575952,0.0003731739,0.001428107,0.3178555,0.001039661,0.004404723,0.00003090485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973387,0.001218635,0.0006044401,0.00002936628,0.0000125438,0.0000191426,0.0001064638,0.00002532304,0.0006453352],"genre_scores_gemma":[0.9973004,0.0009947066,0.00085954,0.00003734394,0.00001643484,0.00001847755,0.000302963,0.000005769715,0.000464342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007774286,"threshold_uncertainty_score":0.002600729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01289357336061145,"score_gpt":0.261685283706718,"score_spread":0.2487917103461065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}