{"id":"W3131140405","doi":"10.1016/j.bpj.2020.11.1374","title":"Non-Classical Protein Kinase a Activation by Aggregation of the PKA R-Subunits as a Mechanism of Inherited Carney Complex Mutations","year":2021,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Allosteric regulation; Protein subunit; Protein kinase A; Phenotype; Mutation; Mutant; Carney complex; Kinase; Chemistry; Enzyme; Phosphorylation; Biochemistry; Biology; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003383923,0.001253139,0.0003635582,0.001244086,0.0005147061,0.0004064326,0.0007319657,0.000938979,0.002109426],"category_scores_gemma":[0.0006344401,0.0003489454,0.000534793,0.0003376617,0.001240606,0.0004009366,0.0007750644,0.0008563403,0.0003030543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007132898,"about_ca_system_score_gemma":0.000398267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001660455,"about_ca_topic_score_gemma":0.0008688867,"domain_scores_codex":[0.9995711,0.00008308805,0.00009602371,0.000103332,0.00009674989,0.00004959483],"domain_scores_gemma":[0.9993973,0.0001413346,0.0002476897,0.00006662672,0.00003181332,0.0001152656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001119425,0.0001212952,0.003140111,0.00009515577,0.0001110328,0.02545249,0.000212955,0.001106634,0.9614881,0.003420894,0.0005154832,0.003216255],"study_design_scores_gemma":[0.0002057933,0.0004799519,0.01920876,0.00003065572,0.0001851614,0.05209212,0.0001869988,0.006729778,0.9146196,0.001192846,0.005001674,0.00006674234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930391,0.000731427,0.004178094,0.0002964474,0.00007753512,0.00004088644,0.0003324591,0.0001965252,0.001107633],"genre_scores_gemma":[0.9977086,0.0001781706,0.001056657,0.00004347639,0.00001627031,0.00001703442,0.00009866303,0.00004217631,0.0008390129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002109426,"threshold_uncertainty_score":0.007056773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0169622092030021,"score_gpt":0.265389085682802,"score_spread":0.2484268764797999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}