{"id":"W3131151712","doi":"10.1055/s-0040-1722623","title":"Simoctocog Alfa (Nuwiq) in Previously Untreated Patients with Severe Haemophilia A: Final Results of the NuProtect Study","year":2021,"lang":"en","type":"article","venue":"Thrombosis and Haemostasis","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Institute for Clinical Evaluative Sciences; BC Children's Hospital; SickKids Foundation; Hospital for Sick Children; University of Alberta","funders":"Octapharma","keywords":"Medicine; Haemophilia; Haemophilia A; Titer; Internal medicine; Gastroenterology; Interquartile range; Immunology; Surgery; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001908868,0.0005196384,0.000808419,0.0002244279,0.0002090951,0.0006603675,0.0002943933,0.0004324169,0.0009150176],"category_scores_gemma":[0.0009420983,0.0002221565,0.000900859,0.0002872383,0.0004051553,0.00038193,0.0002944545,0.0005046144,0.0001997295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003915663,"about_ca_system_score_gemma":0.0004788648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007766252,"about_ca_topic_score_gemma":0.0007635924,"domain_scores_codex":[0.9992823,0.0004159417,0.00004635646,0.00009175562,0.0001084555,0.00005526765],"domain_scores_gemma":[0.9990864,0.0002197052,0.0003004775,0.00007306146,0.0000744076,0.0002458745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2301805,0.007854889,0.6521693,0.0006607216,0.005441659,0.001169409,0.0005903891,0.001060311,0.01860125,0.0002434924,0.001621578,0.08040656],"study_design_scores_gemma":[0.0390494,0.1784519,0.7686971,0.0001102707,0.00237866,0.002024028,0.0002902582,0.0009582207,0.003430131,0.0001056877,0.004452396,0.00005183561],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974844,0.001868981,0.00006674451,0.00003028735,0.00000750248,0.00007102003,0.0001959232,0.000002801409,0.0002723619],"genre_scores_gemma":[0.997869,0.000881543,0.0001524267,0.00008036818,0.00003130434,0.00005724188,0.0006114194,0.000002086215,0.0003146236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001908868,"threshold_uncertainty_score":0.01009518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06384310137971798,"score_gpt":0.3222342260774937,"score_spread":0.2583911246977757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}