{"id":"W3131151712","doi":"10.1055/s-0040-1722623","title":"Simoctocog Alfa (Nuwiq) in Previously Untreated Patients with Severe Haemophilia A: Final Results of the NuProtect Study","year":2021,"lang":"en","type":"article","venue":"Thrombosis and Haemostasis","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Institute for Clinical Evaluative Sciences; BC Children's Hospital; SickKids Foundation; Hospital for Sick Children; University of Alberta","funders":"Octapharma","keywords":"Medicine; Haemophilia; Haemophilia A; Titer; Internal medicine; Gastroenterology; Interquartile range; Immunology; Surgery; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002616497,0.0002277533,0.0005716973,0.00009554713,0.0001427982,0.00002519396,0.0001095795,0.00009396127,0.0001020732],"category_scores_gemma":[0.000157652,0.0001258402,0.00008468624,0.000766225,0.0001642447,0.0000699274,0.0001435741,0.0002541571,0.000005344027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000819159,"about_ca_system_score_gemma":0.0002188944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004849255,"about_ca_topic_score_gemma":0.0007706879,"domain_scores_codex":[0.9980514,0.0002039797,0.0003947817,0.0004450366,0.000558839,0.0003459652],"domain_scores_gemma":[0.9988142,0.0001008366,0.0001064681,0.0005709304,0.0002849205,0.0001226357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001393383,0.002838583,0.975765,0.0001433149,0.0003778957,0.00008118265,0.002030745,0.000005374357,0.0001455539,0.000007571404,0.0005194456,0.01669187],"study_design_scores_gemma":[0.016298,0.001667264,0.975399,0.0004762808,0.0002892031,0.00001288198,0.0007511529,0.00001644666,0.004716668,0.00003209985,0.0001921616,0.0001488899],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938735,0.0001827927,3.588565e-7,0.002308839,0.00002598084,0.00235745,0.00008818699,0.00001816485,0.001144773],"genre_scores_gemma":[0.9988111,0.0001796437,0.0001200848,0.00007941011,0.00002061154,0.00006703846,0.00005971887,0.00002390194,0.000638509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01654298,"threshold_uncertainty_score":0.5131616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06384310137971798,"score_gpt":0.3222342260774937,"score_spread":0.2583911246977757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}