{"id":"W3131158196","doi":"10.1093/ehjcvp/pvab016","title":"Cardiac and cardiometabolic phenotyping of trastuzumab-mediated cardiotoxicity: a secondary analysis of the MANTICORE trial","year":2021,"lang":"en","type":"article","venue":"European Heart Journal - Cardiovascular Pharmacotherapy","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; University of Manitoba; St. Boniface Hospital; Canadian VIGOUR Centre; University of Alberta","funders":"Canadian Institutes of Health Research; University Hospital Foundation; Heart and Stroke Foundation of Canada","keywords":"Trastuzumab; Cardiotoxicity; Medicine; Internal medicine; Breast cancer; Cardiology; Natriuretic peptide; Brain natriuretic peptide; Oncology; Cardiac function curve; Troponin; Cancer; Chemotherapy; Heart failure; Myocardial infarction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002915089,0.0003497385,0.002281236,0.0005163432,0.000227199,0.00005925432,0.0001959665,0.0001086972,0.0001070354],"category_scores_gemma":[0.0001479856,0.0002804677,0.006399473,0.002148053,0.0002422204,0.0001486196,0.00007843038,0.0008046222,0.000002674259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009709723,"about_ca_system_score_gemma":0.0004033054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002159699,"about_ca_topic_score_gemma":9.939982e-7,"domain_scores_codex":[0.9947304,0.002292385,0.0009295563,0.0004737274,0.001187994,0.0003860001],"domain_scores_gemma":[0.9978195,0.000153297,0.0003256797,0.0008834375,0.0005379053,0.0002801103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001944851,0.0001721653,0.005016571,0.0001552539,0.06881481,0.0001130767,0.001096905,0.0005968967,0.8812953,0.00001073242,0.0002879494,0.04049546],"study_design_scores_gemma":[0.04968877,0.0002523169,0.171032,0.0002889694,0.02672066,0.001408738,0.0006475374,0.0003237591,0.6827849,0.00001430995,0.06627971,0.000558374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9605626,0.03475172,0.0008466378,0.0002305385,0.0008091474,0.0007234223,0.00008991631,0.00003331467,0.001952691],"genre_scores_gemma":[0.9880674,0.009913349,0.0002377257,0.0005026618,0.001082266,0.000007263835,0.0000258964,0.00008870193,0.00007469792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1985104,"threshold_uncertainty_score":0.9999648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03248019244406682,"score_gpt":0.2941583417594079,"score_spread":0.2616781493153411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}