{"id":"W3131158455","doi":"10.1016/j.chemphyslip.2021.105063","title":"Multisite interactions of prions with membranes and native nanodiscs","year":2021,"lang":"en","type":"article","venue":"Chemistry and Physics of Lipids","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates","keywords":"Chemistry; Membrane; Scrapie; Biophysics; Nanodisc; Lipid bilayer; Membrane protein; Myristoylation; Membrane lipids; Biochemistry; Prion protein; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000231832,0.00007493566,0.0001072811,0.000002243066,0.00003942681,0.00000657802,0.00003772965,0.00003580822,0.00001773024],"category_scores_gemma":[0.00002660633,0.00006840753,0.00003499283,0.00004711038,0.0001335779,0.000005432018,0.00006815043,0.00004301625,6.50475e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001561499,"about_ca_system_score_gemma":0.00003414095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005068799,"about_ca_topic_score_gemma":0.000002167125,"domain_scores_codex":[0.9996397,0.000008317101,0.00009132025,0.0001503291,0.00004856173,0.00006176826],"domain_scores_gemma":[0.9996329,0.00001767724,0.00006983541,0.0001323758,0.0001019305,0.00004527332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000486549,0.00005698315,0.001766613,0.0002806213,0.00006954942,7.4687e-7,0.00009287165,0.00001090554,0.9908913,0.00007161032,0.00002679793,0.006683286],"study_design_scores_gemma":[0.0002994738,0.00003095368,0.0004972071,0.00007313811,0.00003037422,0.00001086035,0.0002429535,0.00003538374,0.9957284,0.0001627583,0.002805963,0.00008258893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995306,0.003302213,0.0003903993,0.0000486319,0.00001548758,0.00003746838,0.00006468453,0.000002406327,0.0008327056],"genre_scores_gemma":[0.9977663,0.001057621,0.0007545771,0.00001649201,0.00009298159,0.000004753204,0.00006715245,0.000006100585,0.0002339895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006600698,"threshold_uncertainty_score":0.2789578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007139403938296511,"score_gpt":0.2451877302077607,"score_spread":0.2380483262694642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}