{"id":"W3131174931","doi":"10.1007/s00401-021-02275-6","title":"Plasma p-tau231: a new biomarker for incipient Alzheimer’s disease pathology","year":2021,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":719,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"Medical Research Council; Canadian Institutes of Health Research; Sahlgrenska Universitetssjukhuset; Cerveau Technologies; Alzheimer's Society; Göteborgs Universitet; McGill University","keywords":"Neuropathology; Biomarker; Medicine; Dementia; Pathology; Cerebrospinal fluid; Positron emission tomography; Amyloidosis; Amyloid (mycology); Internal medicine; Alzheimer's disease; Standardized uptake value; Oncology; Disease; Nuclear medicine; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001974075,0.0003235901,0.0004458577,0.0001163005,0.0001904877,0.0000453004,0.0002011826,0.0001468642,0.0008453229],"category_scores_gemma":[0.001479522,0.000252425,0.0003450039,0.0003056189,0.0001494108,0.00009624962,0.0002794884,0.000230127,0.0002529518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003843628,"about_ca_system_score_gemma":0.001069315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004096721,"about_ca_topic_score_gemma":0.000003043834,"domain_scores_codex":[0.9972856,0.0002557331,0.0003414445,0.0008714706,0.0005192058,0.0007265207],"domain_scores_gemma":[0.9971192,0.0002693548,0.00009762243,0.0007859876,0.0002328646,0.001494964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.0161909,0.01171921,0.2430925,0.0003049225,0.008160843,0.46696,0.0003088578,0.000005605025,0.02821472,0.001642362,0.08414735,0.1392527],"study_design_scores_gemma":[0.01086651,0.002045107,0.9264067,0.0001311704,0.003082869,0.004720113,0.00006024135,0.0007075587,0.005422633,0.001190993,0.04467249,0.0006936083],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771492,0.008926142,0.00008684491,0.009690762,0.0003238941,0.001169275,0.0002101927,0.0002263148,0.002217382],"genre_scores_gemma":[0.99411,0.00072943,0.001046511,0.002848425,0.000182116,0.0001981832,0.0003691002,0.00005899158,0.0004571716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6833142,"threshold_uncertainty_score":0.9999928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08583986844033618,"score_gpt":0.3414528762927406,"score_spread":0.2556130078524044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}