{"id":"W3131211776","doi":"10.1158/1538-7445.sabcs20-ot-28-01","title":"Abstract OT-28-01: HER2CLIMB-02: A randomized, double-blind, phase 3 study of tucatinib or placebo with T-DM1 for unresectable locally-advanced or metastatic HER2+ breast cancer","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Taxane; Capecitabine; Metastatic breast cancer; Internal medicine; Oncology; Placebo; Nausea; Gastroenterology; Breast cancer; Trastuzumab; Phases of clinical research; Cancer; Surgery; Clinical trial; Colorectal cancer; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002157391,0.00217022,0.003391035,0.0006231751,0.0007456168,0.001550054,0.001359061,0.002329791,0.01103157],"category_scores_gemma":[0.001429568,0.00112312,0.001667739,0.0005232283,0.001764786,0.001331061,0.0004159406,0.004755132,0.00225806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008314839,"about_ca_system_score_gemma":0.001763976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001466231,"about_ca_topic_score_gemma":0.002949001,"domain_scores_codex":[0.9994422,0.0002704413,0.00002786388,0.000119411,0.00004075573,0.00009933813],"domain_scores_gemma":[0.9991014,0.0001954075,0.0001425617,0.00006933831,0.00006173425,0.0004296497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9638778,0.02139237,0.0001842136,0.0004249153,0.000415157,0.00003186501,0.00003841506,0.0002163622,0.004138742,0.0000866332,0.00087447,0.008319087],"study_design_scores_gemma":[0.9344639,0.06401025,0.0004265067,0.00001275644,0.0001303217,0.00001621748,0.00001138144,0.0002370866,0.0003113545,0.00006803291,0.000302811,0.0000094139],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758946,0.003955349,0.001115161,0.0008454744,0.0008945835,0.01107832,0.002313381,0.0004332453,0.003469944],"genre_scores_gemma":[0.9734388,0.003025287,0.001883321,0.001663765,0.0006036801,0.01002501,0.001765336,0.00007983985,0.007515027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01103157,"threshold_uncertainty_score":0.03690428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1485206845789407,"score_gpt":0.4857765730134932,"score_spread":0.3372558884345525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}