{"id":"W3131214209","doi":"10.3390/pharmaceutics13020257","title":"Sulfated Lactosyl Archaeol Archaeosomes Synergize with Poly(I:C) to Enhance the Immunogenicity and Efficacy of a Synthetic Long Peptide-Based Vaccine in a Melanoma Tumor Model","year":2021,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"National Research Council Canada","keywords":"Immunogenicity; Epitope; Adjuvant; Immune system; Antigen; Cancer vaccine; CD8; Cancer immunotherapy; Cytotoxic T cell; Biology; Immunotherapy; Chemistry; Cancer research; Immunology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004148294,0.0002955524,0.0004858552,0.00017264,0.0001515769,0.00001417367,0.0003361118,0.00009456942,0.0001265724],"category_scores_gemma":[0.0002058431,0.0002131024,0.00009255963,0.0004835445,0.0003414348,0.00006243719,0.0001873326,0.0004802437,0.00001681784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004522351,"about_ca_system_score_gemma":0.000300871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001247813,"about_ca_topic_score_gemma":0.0001404104,"domain_scores_codex":[0.998029,0.0005316223,0.0004719416,0.0003771819,0.00008049639,0.0005097847],"domain_scores_gemma":[0.998246,0.0009020527,0.000158412,0.0005213818,0.0001355647,0.00003662374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008992777,0.0004573792,0.005126439,0.00007534085,0.0003841216,0.00006177808,0.002597959,0.001448595,0.9734675,0.00009752795,0.00001626192,0.007274273],"study_design_scores_gemma":[0.004083658,0.000259965,0.01371669,0.000220974,0.0001114053,0.0002073864,0.0002223883,0.001350153,0.9784616,0.00003321567,0.001052917,0.0002796815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9711198,0.02496395,0.00145428,0.001785043,0.00009488031,0.000473868,0.00003998677,0.00003803565,0.00003010853],"genre_scores_gemma":[0.997532,0.0006770861,0.0003126003,0.000814332,0.000007027611,0.00005018397,0.0000233473,0.00003831986,0.000545142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02641212,"threshold_uncertainty_score":0.8690063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01684042995194665,"score_gpt":0.2947870146758417,"score_spread":0.2779465847238951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}