{"id":"W3131214209","doi":"10.3390/pharmaceutics13020257","title":"Sulfated Lactosyl Archaeol Archaeosomes Synergize with Poly(I:C) to Enhance the Immunogenicity and Efficacy of a Synthetic Long Peptide-Based Vaccine in a Melanoma Tumor Model","year":2021,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"National Research Council Canada","keywords":"Immunogenicity; Epitope; Adjuvant; Immune system; Antigen; Cancer vaccine; CD8; Cancer immunotherapy; Cytotoxic T cell; Biology; Immunotherapy; Chemistry; Cancer research; Immunology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001838524,0.0004162762,0.000175013,0.0001478705,0.00008412117,0.0001692403,0.0001391333,0.000278001,0.0004992642],"category_scores_gemma":[0.00008017672,0.0001105865,0.0002018117,0.00008674026,0.0001615113,0.0001841284,0.0001534664,0.0005567378,0.0001435743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001495271,"about_ca_system_score_gemma":0.0001723885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003121747,"about_ca_topic_score_gemma":0.000447894,"domain_scores_codex":[0.9998844,0.00002907845,0.000009965119,0.00001828222,0.0000252076,0.0000330466],"domain_scores_gemma":[0.9999307,0.00001104314,0.00001959563,0.000007395557,0.000008262166,0.00002301602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002838422,0.0001006936,0.00005944315,0.00003282615,0.00000352733,0.0000187278,0.00001001579,0.0001263205,0.9986663,0.00003164438,0.00001949609,0.0006471721],"study_design_scores_gemma":[0.0000397493,0.00260925,0.001142389,0.000005221597,0.00001525726,0.00006910967,0.00001241077,0.001102186,0.9943295,0.00001506488,0.000656767,0.000003171166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982627,0.0003746919,0.0007455835,0.00003416233,0.00002029165,0.00003479957,0.00006462033,0.00001662077,0.0004465055],"genre_scores_gemma":[0.9970754,0.0003501026,0.001365393,0.00003457726,0.000009766601,0.00004590465,0.0001191328,0.000007665659,0.0009919603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004992642,"threshold_uncertainty_score":0.001670241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01684042995194665,"score_gpt":0.2947870146758417,"score_spread":0.2779465847238951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}