{"id":"W3131234768","doi":"10.3390/curroncol28010091","title":"A Histone Acetylation Modulator Gene Signature for Classification and Prognosis of Breast Cancer","year":2021,"lang":"en","type":"article","venue":"Current Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Natural Science Foundation of China","keywords":"Acetylation; Histone; Breast cancer; Epigenetics; Cancer research; Cancer epigenetics; HDAC4; Medicine; Histone deacetylase 2; Gene; Biology; Histone H2A; Cancer; Computational biology; Genetics; Histone methyltransferase; Histone deacetylase","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003286942,0.0002271666,0.0003948961,0.0009794314,0.0001685057,0.0003099517,0.0001342072,0.00015994,0.000833888],"category_scores_gemma":[0.0005847828,0.00005576461,0.0002679578,0.0009834816,0.0001148326,0.0001252261,0.0002145524,0.0001711593,0.0001831855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001710063,"about_ca_system_score_gemma":0.000272574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001284169,"about_ca_topic_score_gemma":0.004085417,"domain_scores_codex":[0.9998467,0.00003365895,0.00001435632,0.00004092552,0.00003514943,0.00002922431],"domain_scores_gemma":[0.9996855,0.0001039867,0.00009152874,0.00002942174,0.00004764829,0.00004188198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007142393,0.00003050603,0.9067425,0.0001038768,0.0002635605,0.0001207861,0.00003883527,0.0005959122,0.05823091,0.00005810642,0.0004707187,0.03263008],"study_design_scores_gemma":[0.00001408198,0.0001802371,0.9875419,0.00001664266,0.0003431879,0.0004464108,0.00007289812,0.002269752,0.007383051,0.0001539947,0.001568745,0.000009113685],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922045,0.002081785,0.001606796,0.00008607622,0.00001660366,0.00002749532,0.003042087,0.00005233283,0.0008823115],"genre_scores_gemma":[0.9954609,0.0003458024,0.0016589,0.00003563065,0.00001288435,0.00001466241,0.002200784,0.000006211669,0.0002641755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001284169,"threshold_uncertainty_score":0.002789676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07673060178725258,"score_gpt":0.4234210414252021,"score_spread":0.3466904396379495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}