{"id":"W3131273798","doi":"10.1038/s41467-021-24968-y","title":"Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; McGill University; Université de Montréal; McGill University Health Centre","funders":"Instituto de Salud Carlos III; Canadian Institutes of Health Research; McGill University Health Centre; Réseau Québécois de Recherche sur les Médicaments; McGill University","keywords":"G protein-coupled receptor; Internalization; Endosome; Cell biology; Endocytosis; Receptor; Signal transduction; Protein kinase B; Cell signaling; Biology; Chemistry; Intracellular; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002386158,0.0009367772,0.0007219597,0.0007770424,0.0002357376,0.0004753638,0.0004213479,0.0005209367,0.001568924],"category_scores_gemma":[0.0002542626,0.0002694352,0.0005043559,0.0004162551,0.0001596672,0.0002125142,0.0003435876,0.0006759276,0.0007119876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004571597,"about_ca_system_score_gemma":0.0003924501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005837412,"about_ca_topic_score_gemma":0.001761169,"domain_scores_codex":[0.9997235,0.00003478547,0.00002045992,0.00004851166,0.0001264199,0.00004622089],"domain_scores_gemma":[0.9998971,0.00001842679,0.0000165697,0.000008955281,0.00002670943,0.00003224779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001426328,0.0002722826,0.0003900633,0.00007505008,0.0000452005,0.000250161,0.00001549563,0.00111366,0.9880337,0.0002613609,0.0004484932,0.008951816],"study_design_scores_gemma":[0.0001521026,0.001532656,0.001875634,0.00001497658,0.0001390581,0.001160562,0.0000260368,0.00625455,0.9786861,0.0001221986,0.0100112,0.00002492967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9428495,0.004098678,0.03567795,0.0007004603,0.00009562787,0.0009077204,0.004136209,0.0009682705,0.01056558],"genre_scores_gemma":[0.9626223,0.00344425,0.01981739,0.0002986751,0.00001981299,0.0003132229,0.004594275,0.0001075539,0.008782408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001568924,"threshold_uncertainty_score":0.005248547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01335141330569704,"score_gpt":0.2671141787067583,"score_spread":0.2537627654010612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}