{"id":"W3131304437","doi":"10.1371/journal.pgen.1009265","title":"yama, a mutant allele of Mov10l1, disrupts retrotransposon silencing and piRNA biogenesis","year":2021,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Child Health and Human Development; Hospital for Sick Children; National Cancer Institute; Human Frontier Science Program; National Institutes of Health; Memorial Sloan-Kettering Cancer Center; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Howard Hughes Medical Institute","keywords":"Piwi-interacting RNA; Biology; Transposable element; Genetics; RNA Helicase A; Retrotransposon; Biogenesis; RasiRNA; Gene silencing; Germline; Germ cell; Mutation; Spermatid; RNA interference; Cell biology; Mutant; RNA; Helicase; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000467785,0.000103556,0.0001594127,0.000007224624,0.0001026141,0.00002871303,0.0000982152,0.00008104946,0.0003199901],"category_scores_gemma":[0.00003242759,0.00004810403,0.00006112109,0.0002471404,0.0000411997,0.00002514652,0.00005815879,0.00004906761,0.000005411331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007879597,"about_ca_system_score_gemma":0.00001564698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003474628,"about_ca_topic_score_gemma":0.0006264478,"domain_scores_codex":[0.9991539,0.00004414922,0.0002072354,0.0002422048,0.0001783701,0.0001741366],"domain_scores_gemma":[0.9996035,0.00007827989,0.00005834705,0.00007213056,0.0001000003,0.00008772996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004683328,0.00009999001,0.01867755,0.00001612922,0.00002381641,0.0000065303,0.0001924588,0.00001466205,0.9730223,0.00006395685,0.000006694987,0.00787119],"study_design_scores_gemma":[0.0001239309,0.000165873,0.07053248,0.00002765565,0.00005612074,0.00001398348,0.0003181249,0.001207157,0.9260057,0.0005036041,0.0008980562,0.0001473556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971714,0.00173056,0.000004550378,0.0005891533,0.00003732745,0.00009788192,0.0001231116,0.00001887953,0.0002271411],"genre_scores_gemma":[0.9984024,0.0006299475,0.0006812779,0.00007146181,0.0001087875,0.000006479568,0.00004719208,0.000001300584,0.00005116317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05185492,"threshold_uncertainty_score":0.3503667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02167021597626188,"score_gpt":0.2044713917192517,"score_spread":0.1828011757429898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}