{"id":"W3131304437","doi":"10.1371/journal.pgen.1009265","title":"yama, a mutant allele of Mov10l1, disrupts retrotransposon silencing and piRNA biogenesis","year":2021,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Child Health and Human Development; Hospital for Sick Children; National Cancer Institute; Human Frontier Science Program; National Institutes of Health; Memorial Sloan-Kettering Cancer Center; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Howard Hughes Medical Institute","keywords":"Piwi-interacting RNA; Biology; Transposable element; Genetics; RNA Helicase A; Retrotransposon; Biogenesis; RasiRNA; Gene silencing; Germline; Germ cell; Mutation; Spermatid; RNA interference; Cell biology; Mutant; RNA; Helicase; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008162177,0.001021138,0.000289235,0.0006526003,0.000249266,0.0002207835,0.0006972542,0.0007250044,0.00345195],"category_scores_gemma":[0.0001149196,0.000355564,0.0005000052,0.0002306402,0.0005114895,0.0001942332,0.0006570992,0.000730698,0.001758507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003494334,"about_ca_system_score_gemma":0.0002357051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005579476,"about_ca_topic_score_gemma":0.001004552,"domain_scores_codex":[0.9998807,0.00001158557,0.00001566251,0.0000385148,0.00002985688,0.0000238186],"domain_scores_gemma":[0.9996051,0.00005296921,0.0001961771,0.00002154055,0.00001238008,0.0001118047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004192684,0.00001781326,0.0001420816,0.00002276501,0.000005560109,0.000273505,0.00000861993,0.0000338436,0.9986284,0.00007260139,0.00003963773,0.0007132614],"study_design_scores_gemma":[0.00005522288,0.0003307554,0.009625591,0.00001901539,0.00004091116,0.003571189,0.00007076275,0.001654187,0.9774699,0.0001030347,0.007037336,0.00002204724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890481,0.0006442781,0.006042205,0.0001410432,0.00007248599,0.0000598988,0.001430055,0.000546368,0.002015573],"genre_scores_gemma":[0.9809121,0.0005434968,0.004546962,0.00008464202,0.00002079205,0.0001073338,0.002115732,0.0002257049,0.01144327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00345195,"threshold_uncertainty_score":0.01154792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02167021597626188,"score_gpt":0.2044713917192517,"score_spread":0.1828011757429898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}