{"id":"W3131328635","doi":"10.3389/fnagi.2021.638922","title":"TNFRSF1B Gene Variants and Related Soluble TNFR2 Levels Impact Resilience in Alzheimer's Disease","year":2021,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; University of Southern California; Biogen; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Alzheimer's Disease Neuroimaging Initiative; Oncology; Cerebrospinal fluid; Internal medicine; Cohort; Dementia; Medicine; Frontotemporal dementia; Disease; Single-nucleotide polymorphism; Longitudinal study; Clinical Dementia Rating; Neuroimaging; Cognitive decline; Cohort study; Psychology; Neuroscience; Gene; Pathology; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000673438,0.0004300632,0.0003203768,0.0002982424,0.0003275253,0.0003723839,0.0002057254,0.0004058478,0.001337893],"category_scores_gemma":[0.001465471,0.0002248019,0.000517303,0.0002733555,0.000245515,0.0002326283,0.0002673793,0.0004308767,0.0002208341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000258354,"about_ca_system_score_gemma":0.0001819274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003174143,"about_ca_topic_score_gemma":0.003117123,"domain_scores_codex":[0.9997769,0.00007110393,0.00002089272,0.00006793565,0.00002356998,0.00003961926],"domain_scores_gemma":[0.9995136,0.0000885714,0.0002329041,0.00006080084,0.00003695489,0.00006711107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002539819,0.0001519023,0.9860718,0.00001793223,0.0003733955,0.0003237064,0.0002095432,0.0001784379,0.004408617,0.00006212146,0.0001714223,0.005491249],"study_design_scores_gemma":[0.00003314116,0.0002253171,0.9985153,0.000006299012,0.00009810949,0.0003248424,0.00006332799,0.0002067115,0.0002747904,0.0001026618,0.0001454408,0.000004102854],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995639,0.0001712577,0.00004344551,0.00003797173,0.000002668275,0.000001693546,0.00008162621,0.000002543613,0.00009492242],"genre_scores_gemma":[0.9996649,0.00004460386,0.00005172135,0.00001618188,0.000003864863,0.000002255604,0.00007579373,0.000001394939,0.0001392545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003174143,"threshold_uncertainty_score":0.006311357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03356772423251528,"score_gpt":0.3223830895433305,"score_spread":0.2888153653108152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}