{"id":"W3131425476","doi":"10.3390/cancers13050942","title":"Prostaglandin E2 Receptor 4 (EP4) as a Therapeutic Target to Impede Breast Cancer-Associated Angiogenesis and Lymphangiogenesis","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brandon University; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Cure Brain Cancer Foundation","keywords":"Lymphangiogenesis; Angiogenesis; Medicine; Cancer research; Metastasis; Breast cancer; Cancer; Cancer cell; Tumor progression; Inflammatory breast cancer; Immune system; Lymphatic system; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002428203,0.0008462321,0.001584959,0.0001815215,0.0002176478,0.0001393549,0.0004386336,0.0007543609,0.000336416],"category_scores_gemma":[0.00005244339,0.000750048,0.0009775026,0.0007023024,0.0001160514,0.000008471758,0.000280941,0.00007650951,0.00002385905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00135886,"about_ca_system_score_gemma":0.003452727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006115186,"about_ca_topic_score_gemma":0.0002092254,"domain_scores_codex":[0.9968318,0.0002504386,0.0004760872,0.001343006,0.0003035549,0.0007950505],"domain_scores_gemma":[0.9982486,0.00003644315,0.0003808773,0.0006590216,0.0002427913,0.0004322471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001083097,0.0000488603,0.0006551371,0.002944881,0.0037729,0.00002271958,0.0001070704,0.00002213048,0.004163678,0.00002583762,0.03470791,0.9534206],"study_design_scores_gemma":[0.0003539837,0.0001646127,0.00004586426,0.002701942,0.001003801,0.00006939997,0.00008794587,0.000002251131,0.00132689,0.000002257834,0.9932517,0.0009893324],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001583149,0.993489,0.00004279941,0.0002263584,0.0006993741,0.0009977258,0.002828175,0.00003776761,0.00009560464],"genre_scores_gemma":[0.0007851784,0.9911261,0.0001331989,0.0007814749,0.001068751,0.001407758,0.001243108,0.0002291524,0.003225312],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9585438,"threshold_uncertainty_score":0.999495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02282463792602759,"score_gpt":0.3161909634533745,"score_spread":0.2933663255273469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}