{"id":"W3131425476","doi":"10.3390/cancers13050942","title":"Prostaglandin E2 Receptor 4 (EP4) as a Therapeutic Target to Impede Breast Cancer-Associated Angiogenesis and Lymphangiogenesis","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brandon University; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Cure Brain Cancer Foundation","keywords":"Lymphangiogenesis; Angiogenesis; Medicine; Cancer research; Metastasis; Breast cancer; Cancer; Cancer cell; Tumor progression; Inflammatory breast cancer; Immune system; Lymphatic system; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001561277,0.0002972063,0.0003805576,0.0005073973,0.0001095937,0.0003638803,0.0002229786,0.0004278341,0.001743324],"category_scores_gemma":[0.0001130191,0.0001004331,0.0002594302,0.0003176499,0.0001594988,0.0003231656,0.0001919012,0.0007873069,0.0006123057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002598322,"about_ca_system_score_gemma":0.0002385001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003240389,"about_ca_topic_score_gemma":0.0006701394,"domain_scores_codex":[0.9999495,0.00001009482,0.000004776454,0.000008744094,0.00001672213,0.00001027553],"domain_scores_gemma":[0.9999766,0.000007027742,0.000005446874,0.000001156834,0.00000583957,0.000003797001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005599465,0.0002560081,0.0005487801,0.01171193,0.0001674258,0.001373265,0.0001117862,0.001661092,0.1759802,0.01615197,0.03230424,0.7591733],"study_design_scores_gemma":[0.0001325822,0.001002887,0.002194542,0.0006571043,0.0002784544,0.003399052,0.0000549937,0.0007920085,0.05461058,0.002939531,0.9339056,0.00003261695],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01057962,0.9765029,0.003262435,0.001246119,0.0006440721,0.00004812099,0.0001935846,0.00008733784,0.007435865],"genre_scores_gemma":[0.06071297,0.9271902,0.002486402,0.0008974289,0.0003512382,0.00007024596,0.0002312657,0.00001202564,0.008048168],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001743324,"threshold_uncertainty_score":0.005831957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02282463792602759,"score_gpt":0.3161909634533745,"score_spread":0.2933663255273469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}