{"id":"W3131453373","doi":"10.1158/2159-8290.cd-20-1098","title":"PTHrP Drives Pancreatic Cancer Growth and Metastasis and Reveals a New Therapeutic Vulnerability","year":2021,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health; U.S. Department of Defense","keywords":"Pancreatic cancer; Metastasis; Cancer research; KRAS; Cancer; Downregulation and upregulation; Osteopontin; Medicine; Biology; Internal medicine; Gene; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001260392,0.0001825721,0.0001957506,0.0001647197,0.00009424415,0.0004359648,0.0001449417,0.0002614163,0.001274837],"category_scores_gemma":[0.00007094853,0.00008442711,0.0001353325,0.0001152521,0.0003720951,0.0002374256,0.0002389004,0.0008244661,0.0002408715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003074545,"about_ca_system_score_gemma":0.0001910799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001481732,"about_ca_topic_score_gemma":0.0002484043,"domain_scores_codex":[0.9999288,0.000007789289,0.000004505052,0.0000132695,0.00003101796,0.00001453627],"domain_scores_gemma":[0.9999474,0.000006919034,0.00001664526,0.000006138635,0.000006767359,0.00001598944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002420541,0.00005938005,0.0007229995,0.00009565717,0.000008495589,0.0003988259,0.00002706724,0.0001250422,0.9798104,0.001796238,0.0006443926,0.0160695],"study_design_scores_gemma":[0.0001341502,0.002019817,0.01828066,0.00003671211,0.00007574185,0.005796825,0.0001453203,0.001449702,0.9188641,0.00210339,0.05107756,0.00001605667],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9416004,0.02821098,0.008751673,0.004226271,0.0002829242,0.0000657901,0.0004206196,0.0003579989,0.01608327],"genre_scores_gemma":[0.9822586,0.009662057,0.001897388,0.0003189883,0.00012998,0.00001841428,0.0001422181,0.00001686592,0.005555522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001274837,"threshold_uncertainty_score":0.004264712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05182404384628446,"score_gpt":0.3734468875279632,"score_spread":0.3216228436816787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}