{"id":"W3131502825","doi":"10.1038/s41419-021-03491-4","title":"Distinct Ring1b complexes defined by DEAD-box helicases and EMT transcription factors synergistically enhance E-cadherin silencing in breast cancer","year":2021,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Natural Science Foundation of China; University of Bristol; Northeast Normal University","keywords":"Epigenetics; Epithelial–mesenchymal transition; Cancer research; Transcription factor; CDH1; Gene silencing; Cadherin; Biology; Breast cancer; Metastasis; Cell biology; Cancer; Bioinformatics; Cell; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000188228,0.0002186549,0.0002157241,0.0002099355,0.0001388547,0.0002389792,0.0001343363,0.0001653679,0.001382859],"category_scores_gemma":[0.000117791,0.0001704464,0.0001806031,0.00009904349,0.0001634017,0.0001658434,0.0002585307,0.0003148633,0.0002552954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000270708,"about_ca_system_score_gemma":0.0001150368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002927769,"about_ca_topic_score_gemma":0.0008159586,"domain_scores_codex":[0.9998162,0.00004979645,0.00001312139,0.00003664589,0.00004598248,0.00003828637],"domain_scores_gemma":[0.9999462,0.000007004545,0.00001208089,0.000006438561,0.000005432174,0.00002273643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009348983,0.00001375422,0.0002426931,0.00002855519,0.000006771993,0.0000240217,0.000008881766,0.00004090642,0.9983084,0.00008538739,0.00004951929,0.00109756],"study_design_scores_gemma":[0.00002286247,0.0001924741,0.007757751,0.000003664675,0.00001856329,0.0002388742,0.0000208158,0.0009976224,0.9882936,0.00004541779,0.002404937,0.00000333788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900804,0.005093943,0.002637408,0.0001041295,0.00003246099,0.00001971083,0.0001224401,0.00007303103,0.001836522],"genre_scores_gemma":[0.997006,0.000521026,0.0007980878,0.0000361094,0.000004710607,0.00001196751,0.0001137602,0.000006993447,0.001501368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001382859,"threshold_uncertainty_score":0.004626095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01100277808811863,"score_gpt":0.2508606986143735,"score_spread":0.2398579205262549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}