{"id":"W3131619507","doi":"10.1016/j.apsb.2021.02.011","title":"Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase","year":2021,"lang":"en","type":"article","venue":"Acta Pharmaceutica Sinica B","topic":"Phytochemistry and Bioactivity Studies","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Infrastructure for Microbiological Resources; Natural Science Foundation of Beijing Municipality; Chinese Academy of Meteorological Sciences; National Natural Science Foundation of China","keywords":"RNA polymerase; Proofreading; RNA-dependent RNA polymerase; Coronavirus; Polymerase; Nucleoside; Nucleoside triphosphate; Population; RNA; Virology; Biology; Chemistry; Enzyme; Biochemistry; Nucleotide; Coronavirus disease 2019 (COVID-19); Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00112844,0.0005533259,0.0005959101,0.00006629475,0.0007151909,0.00008889641,0.0005312808,0.000510567,0.0007410474],"category_scores_gemma":[0.0007254503,0.0005875441,0.0002536679,0.0004512949,0.0003992211,0.0003941648,0.0004941467,0.001772314,0.0002173661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001894859,"about_ca_system_score_gemma":0.0002439144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001732143,"about_ca_topic_score_gemma":0.000004854809,"domain_scores_codex":[0.9957399,0.0007378354,0.000823917,0.001256461,0.0004229106,0.001018922],"domain_scores_gemma":[0.9974573,0.0007641286,0.0004010499,0.000757088,0.0002639755,0.000356488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004398399,0.0009904596,0.0005319574,0.00006994585,0.0004320483,0.00009145831,0.0002059338,0.000002181557,0.840472,0.00005442287,0.1468151,0.009894609],"study_design_scores_gemma":[0.00162011,0.00004614737,0.00004062278,0.00001672638,0.0002576702,0.00004643416,0.00009979774,0.0003049611,0.6511968,0.00006856989,0.3458719,0.0004302762],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9532989,0.004946008,0.00004867038,0.01955436,0.001577723,0.0005184287,0.0005009364,0.0003514671,0.01920354],"genre_scores_gemma":[0.9823289,0.00195991,0.0001408765,0.01229973,0.0007198419,0.0001081166,0.000309021,0.00005964084,0.002073941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1990567,"threshold_uncertainty_score":0.9996576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1344219689530184,"score_gpt":0.4527623140518432,"score_spread":0.3183403450988248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}