{"id":"W3131632038","doi":"10.1186/s12885-021-07876-8","title":"Oligosaccharides increase the genotoxic effect of colibactin produced by pks+ Escherichia coli strains","year":2021,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cegep Edouard Montpetit; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Medizinische Fakultät, Westfälische Wilhelms-Universität Münster; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Ministère de la Santé et des Services sociaux; Ministère de la Santé; Canadian Institutes of Health Research; Université de Montréal; Institute of Cancer Research; Institut Du Cancer de Montréal","keywords":"Escherichia coli; Genotoxicity; Microbiology; Biology; Prebiotic; Carcinogenesis; DNA damage; Bacteria; Oligosaccharide; Molecular biology; Chemistry; DNA; Biochemistry; Gene; Genetics; Toxicity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001226083,0.0007146108,0.0002888539,0.0002483207,0.00007490835,0.0002952314,0.0001658363,0.0002884147,0.00169463],"category_scores_gemma":[0.000180844,0.0001238194,0.0002512929,0.0001492902,0.000172883,0.0001464934,0.0002664751,0.0004310304,0.0002694411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002667781,"about_ca_system_score_gemma":0.0002020104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001020064,"about_ca_topic_score_gemma":0.001080356,"domain_scores_codex":[0.9997701,0.00004279535,0.0000240641,0.00003424045,0.00007896915,0.000049765],"domain_scores_gemma":[0.9997839,0.00002950601,0.00007513672,0.00002056574,0.00004378892,0.00004717926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007235818,0.00002941705,0.0001858885,0.00002769906,0.000003593049,0.00002163774,0.000005923343,0.00001671249,0.9993147,0.000009610491,0.0000110052,0.0003014769],"study_design_scores_gemma":[0.000005216423,0.0005035696,0.004743793,0.000007680401,0.00001103389,0.0001078343,0.00002659426,0.0001370804,0.9938256,0.00001121281,0.0006174811,0.000002933664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972556,0.0006439108,0.0008287368,0.00006197162,0.0000214906,0.00002919757,0.0002236768,0.00004171739,0.0008936825],"genre_scores_gemma":[0.9948429,0.0004249389,0.001769217,0.00006190293,0.00000771912,0.00002774142,0.0005803401,0.00002228946,0.002262958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00169463,"threshold_uncertainty_score":0.005669057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009276961745717224,"score_gpt":0.2772377985550708,"score_spread":0.2679608368093536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}