{"id":"W3131673246","doi":"10.1038/s41398-021-01248-3","title":"Genome-wide analysis suggests the importance of vascular processes and neuroinflammation in late-life antidepressant response","year":2021,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; McMaster University; Queen's University; St. Joseph’s Healthcare Hamilton; University of British Columbia; McGill University; Douglas Mental Health University Institute; University Health Network; University of Toronto; Vancouver Coastal Health; Centre for Addiction and Mental Health","funders":"","keywords":"Neuroinflammation; Antidepressant; Schizophrenia (object-oriented programming); Psychology; Neuroscience; Psychiatry; Medicine; Internal medicine; Hippocampus; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006276969,0.0003086475,0.0003702101,0.0005051257,0.0002428966,0.0005387032,0.0002675955,0.0004299231,0.001633888],"category_scores_gemma":[0.001481381,0.0001640499,0.0008426174,0.0007963974,0.0002354335,0.0001708384,0.0002951059,0.0005127034,0.0001382756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001308353,"about_ca_system_score_gemma":0.0001307378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002525092,"about_ca_topic_score_gemma":0.004360988,"domain_scores_codex":[0.9995565,0.0001524054,0.00004438635,0.0001577054,0.00004055191,0.00004841381],"domain_scores_gemma":[0.9987288,0.0004493908,0.0005088876,0.0001285841,0.0000811134,0.0001032909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000599694,0.00003164399,0.98945,0.0000330946,0.0007741498,0.0001432832,0.00004016993,0.0001968864,0.004208789,0.00006173252,0.0001657595,0.004294702],"study_design_scores_gemma":[0.000009110504,0.00004993737,0.9987729,0.000004976396,0.0001814205,0.0001214922,0.00002198105,0.0004841774,0.0001682517,0.00008774912,0.00009565886,0.000002380473],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971564,0.0011396,0.0006786762,0.0001168944,0.00001191994,0.000005347019,0.000558974,0.00001227804,0.0003199154],"genre_scores_gemma":[0.9992735,0.0001452361,0.0002059298,0.0000409601,0.00001050454,0.00000354287,0.0002233955,0.000002522972,0.00009444243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002525092,"threshold_uncertainty_score":0.005465865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01624742784226683,"score_gpt":0.2561147592298925,"score_spread":0.2398673313876256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}