{"id":"W3131673246","doi":"10.1038/s41398-021-01248-3","title":"Genome-wide analysis suggests the importance of vascular processes and neuroinflammation in late-life antidepressant response","year":2021,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; McMaster University; Queen's University; St. Joseph’s Healthcare Hamilton; University of British Columbia; McGill University; Douglas Mental Health University Institute; University Health Network; University of Toronto; Vancouver Coastal Health; Centre for Addiction and Mental Health","funders":"","keywords":"Neuroinflammation; Antidepressant; Schizophrenia (object-oriented programming); Psychology; Neuroscience; Psychiatry; Medicine; Internal medicine; Hippocampus; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002778573,0.0001068645,0.0001701486,0.000149123,0.00008070216,0.0000286818,0.0001332281,0.00004290925,0.00007257588],"category_scores_gemma":[0.0005091085,0.00008819976,0.00009044623,0.001436716,0.0001047256,0.0001572175,0.00001303081,0.0001091591,0.00000218661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003444572,"about_ca_system_score_gemma":0.0002895296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004322112,"about_ca_topic_score_gemma":0.0004682983,"domain_scores_codex":[0.9986466,0.0002386665,0.0003432974,0.0003286641,0.0003043634,0.0001384355],"domain_scores_gemma":[0.999011,0.0005649462,0.0001068898,0.0002238746,0.00005125295,0.00004208427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003083932,0.0001248548,0.9536055,0.0001227225,0.00005528018,0.00000824477,0.0006998781,0.01439591,0.02886868,0.001733196,0.00001409169,0.00006326647],"study_design_scores_gemma":[0.000529764,0.0000117123,0.9910777,0.00001263426,0.00004467027,0.000001983354,0.00006072096,0.0009951058,0.002209389,0.004855453,0.000103159,0.00009773504],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906065,0.001758325,0.0004740242,0.00668038,0.00005188905,0.0001507616,0.00002354173,0.00001897988,0.0002355413],"genre_scores_gemma":[0.9988819,0.0001966775,0.0002549056,0.0005933697,0.00001772781,0.000007333631,0.00001368429,0.000009713954,0.00002468699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03747218,"threshold_uncertainty_score":0.3596682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01624742784226683,"score_gpt":0.2561147592298925,"score_spread":0.2398673313876256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}