{"id":"W3131698633","doi":"10.1007/s10875-021-00991-y","title":"Thymopoiesis, Alterations in Dendritic Cells and Tregs, and Reduced T Cell Activation in Successful Extracorporeal Photopheresis Treatment of GVHD","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Immunology","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Mallinckrodt Pharmaceuticals","keywords":"Extracorporeal Photopheresis; Immunology; T cell; Downregulation and upregulation; Flow cytometry; Dendritic cell; Naive T cell; Regulatory T cell; Medicine; Hematopoietic stem cell; Biology; Stem cell; Graft-versus-host disease; Immune system; Haematopoiesis; IL-2 receptor; T-cell receptor; Gene; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003644284,0.0001036968,0.0006975564,0.0001775098,0.00001589131,0.000008773713,0.00003559778,0.0001916323,0.00009774418],"category_scores_gemma":[0.0001899967,0.00008749581,0.0000894176,0.0001527925,0.000120769,0.00009902394,0.000008742643,0.0002247906,8.07054e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004983563,"about_ca_system_score_gemma":0.0002631534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009154812,"about_ca_topic_score_gemma":0.0001516039,"domain_scores_codex":[0.9978856,0.0003098962,0.001400096,0.0001603957,0.0001158102,0.0001282041],"domain_scores_gemma":[0.998016,0.001237386,0.0004141807,0.0001246983,0.0001402497,0.00006749103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002010022,0.003130968,0.1899677,0.0002449815,0.0002359872,0.0007997759,0.001610705,0.00001294509,0.782487,0.0001303359,0.00002379205,0.01934582],"study_design_scores_gemma":[0.008157861,0.001322086,0.6082852,0.0002536694,0.0001635495,0.0003338326,0.001103085,0.00003498439,0.3799611,0.0002702921,0.00004604022,0.0000682664],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969848,0.001360618,0.0001100373,0.0006121196,0.0001927466,0.0001514136,0.000003454608,0.000002300948,0.0005824468],"genre_scores_gemma":[0.9911646,0.006408799,0.002207702,0.00003705678,0.0000500886,0.00000414179,0.000007640258,0.000008893529,0.00011104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4183176,"threshold_uncertainty_score":0.3567976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04439235378739696,"score_gpt":0.3559546650037586,"score_spread":0.3115623112163616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}