{"id":"W3131735488","doi":"10.1371/journal.pone.0246507","title":"Biomarker-focused multi-drug combination therapy and repurposing trial in mdx mice","year":2021,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"AGADA Biosciences","funders":"Foundation to Eradicate Duchenne","keywords":"Duchenne muscular dystrophy; Prednisolone; Medicine; Dystrophin; Pharmacology; Rituximab; Combination therapy; Biomarker; Internal medicine; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004737696,0.0009198779,0.001663826,0.0006393715,0.0001999805,0.0005038476,0.0004502061,0.0008835496,0.001214209],"category_scores_gemma":[0.0002088425,0.00018807,0.0006416573,0.0002507993,0.0003694138,0.000392487,0.0002448859,0.001222704,0.0002468113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000379844,"about_ca_system_score_gemma":0.0004326016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002904138,"about_ca_topic_score_gemma":0.000947341,"domain_scores_codex":[0.9997782,0.00004703811,0.00001851327,0.00005530437,0.0000316203,0.00006937727],"domain_scores_gemma":[0.999774,0.00001759055,0.00005704242,0.00002150379,0.00002010926,0.0001096722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1842563,0.03886132,0.002856009,0.001064151,0.0007170942,0.0006465375,0.0001958993,0.002088927,0.6746775,0.0004301244,0.001537113,0.09266903],"study_design_scores_gemma":[0.04766117,0.6766444,0.01721355,0.0001670229,0.0009714733,0.0006379522,0.0001423069,0.003034148,0.245177,0.0003137938,0.007944765,0.00009245896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967532,0.001697722,0.0003201193,0.000107758,0.000056995,0.0002839439,0.0002675306,0.00007219177,0.0004405331],"genre_scores_gemma":[0.9897462,0.002478304,0.001774165,0.0003781135,0.00007961096,0.001254896,0.001046415,0.00002127869,0.003220931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001663826,"threshold_uncertainty_score":0.004061937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05850975862570289,"score_gpt":0.2614858061244443,"score_spread":0.2029760474987414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}