{"id":"W3131766563","doi":"10.3390/cancers13040909","title":"Role of PFKFB3 and PFKFB4 in Cancer: Genetic Basis, Impact on Disease Development/Progression, and Potential as Therapeutic Targets","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Ministerstwo Edukacji i Nauki","keywords":"Isozyme; Biology; Phosphofructokinase; Glycolysis; Phosphofructokinase 2; Carcinogenesis; Cancer; Metastasis; Cancer cell; Cancer research; Biochemistry; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009354303,0.0004117635,0.0008845733,0.0001110082,0.000056821,0.00002594385,0.0001576823,0.0002443471,0.00006106246],"category_scores_gemma":[0.00002202097,0.0003341975,0.0002080573,0.0001460507,0.000118091,0.000003762585,0.0001162899,0.0001660494,9.505798e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002111045,"about_ca_system_score_gemma":0.003662193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001792026,"about_ca_topic_score_gemma":0.0001060219,"domain_scores_codex":[0.9983705,0.0001069239,0.0003841647,0.0006312604,0.0001753897,0.0003317283],"domain_scores_gemma":[0.9991406,0.00001155958,0.0002303175,0.0003085314,0.00005981242,0.0002492245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009437086,0.00002066485,0.0001118479,0.001313895,0.0002494057,0.00000570548,0.0000518558,0.00004550286,0.0005285323,0.000004029731,0.0003131359,0.997261],"study_design_scores_gemma":[0.000501766,0.00009264404,0.001781271,0.002605496,0.0003719429,0.00001499783,0.00003809086,0.000007001402,0.0005923076,0.00001385882,0.9935652,0.0004154196],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01813787,0.9807963,0.000004690849,0.000007971247,0.0004221368,0.0004435112,0.0001412792,0.000004699561,0.00004154469],"genre_scores_gemma":[0.008858057,0.9898881,0.00008165215,0.00008653179,0.0005074894,0.0002144928,0.0002165698,0.00005415883,0.00009292048],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9968457,"threshold_uncertainty_score":0.999911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01207531103450745,"score_gpt":0.3215963567868558,"score_spread":0.3095210457523484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}