{"id":"W3131766563","doi":"10.3390/cancers13040909","title":"Role of PFKFB3 and PFKFB4 in Cancer: Genetic Basis, Impact on Disease Development/Progression, and Potential as Therapeutic Targets","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Ministerstwo Edukacji i Nauki","keywords":"Isozyme; Biology; Phosphofructokinase; Glycolysis; Phosphofructokinase 2; Carcinogenesis; Cancer; Metastasis; Cancer cell; Cancer research; Biochemistry; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003824494,0.0004698802,0.0008522872,0.001011814,0.0002307627,0.0007390734,0.0003561358,0.0006501913,0.002924488],"category_scores_gemma":[0.0004404507,0.0001426327,0.000562273,0.001037637,0.0002359522,0.0007973622,0.0003520071,0.0009452146,0.001038981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004634806,"about_ca_system_score_gemma":0.000700993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005765343,"about_ca_topic_score_gemma":0.000653623,"domain_scores_codex":[0.9998688,0.00001741193,0.00002091434,0.00002713321,0.00003828005,0.00002762404],"domain_scores_gemma":[0.9998237,0.00005422329,0.00004344201,0.000005171928,0.00004836675,0.0000251063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00128304,0.0001362471,0.004417541,0.02219423,0.0003506472,0.001482066,0.0002224101,0.0008924426,0.03857039,0.004573291,0.02688235,0.8989955],"study_design_scores_gemma":[0.00008335913,0.0005565032,0.01348522,0.002791385,0.0008749849,0.007040954,0.0002354804,0.0005329218,0.01781991,0.003887266,0.9526162,0.00007572381],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003211341,0.9937516,0.0005016163,0.0005252144,0.0002342274,0.000009019584,0.0001479382,0.00002554171,0.001593479],"genre_scores_gemma":[0.01364496,0.9829753,0.0007063126,0.0002917012,0.000380218,0.00001665822,0.0005034042,0.000007829128,0.001473656],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002924488,"threshold_uncertainty_score":0.009783447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01207531103450745,"score_gpt":0.3215963567868558,"score_spread":0.3095210457523484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}