{"id":"W3131770868","doi":"10.1021/acsnano.0c07680","title":"A Potent Cancer Vaccine Adjuvant System for Particleization of Short, Synthetic CD8<sup>+</sup> T Cell Epitopes","year":2021,"lang":"en","type":"article","venue":"ACS Nano","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; University at Buffalo; McGill University; National Institutes of Health; National Science Foundation","keywords":"Epitope; Adjuvant; Major histocompatibility complex; Antigen; MHC class I; Cytotoxic T cell; CD8; Immune system; Biology; T cell; Chemistry; Immunology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001426922,0.0003688719,0.0001723989,0.0001570731,0.0001054458,0.0002219914,0.0001533197,0.000296494,0.0004825302],"category_scores_gemma":[0.0001173817,0.0001036333,0.0001633494,0.0001204621,0.0001778155,0.000223673,0.000219063,0.0004509277,0.0002837616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002837694,"about_ca_system_score_gemma":0.0002835985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002818497,"about_ca_topic_score_gemma":0.0002658648,"domain_scores_codex":[0.9999123,0.00001550331,0.000007857622,0.0000214802,0.00002307421,0.00001980839],"domain_scores_gemma":[0.9999309,0.00001164795,0.00002263179,0.000007091649,0.00001265416,0.00001510464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002100773,0.00001185637,0.00004843881,0.00002839468,0.000001803538,0.00001891824,0.000004369966,0.00006783201,0.9984869,0.0001035517,0.00002678841,0.001180186],"study_design_scores_gemma":[0.000009148863,0.0001988717,0.0003411346,0.000002184824,0.000008658122,0.0001731007,0.000003722068,0.0005421949,0.996704,0.00002476215,0.001990078,0.000002100451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9337226,0.002746113,0.06053961,0.0003312771,0.00009577849,0.0002711074,0.0003467347,0.0003099573,0.001636839],"genre_scores_gemma":[0.9736626,0.0009600872,0.02238171,0.000116238,0.00002824578,0.0001123372,0.0003950993,0.00003594908,0.002307802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004825302,"threshold_uncertainty_score":0.002058864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01110493161831039,"score_gpt":0.2366183086341058,"score_spread":0.2255133770157954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}