{"id":"W3131770868","doi":"10.1021/acsnano.0c07680","title":"A Potent Cancer Vaccine Adjuvant System for Particleization of Short, Synthetic CD8<sup>+</sup> T Cell Epitopes","year":2021,"lang":"en","type":"article","venue":"ACS Nano","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; University at Buffalo; McGill University; National Institutes of Health; National Science Foundation","keywords":"Epitope; Adjuvant; Major histocompatibility complex; Antigen; MHC class I; Cytotoxic T cell; CD8; Immune system; Biology; T cell; Chemistry; Immunology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002258897,0.0001709477,0.0003956475,0.00006977111,0.0001575777,0.00001247235,0.0001705379,0.0001758414,0.0001927424],"category_scores_gemma":[0.00007997263,0.0001462034,0.000140989,0.0001765385,0.00004976205,0.00007640638,0.00005344507,0.00009107543,0.00004765245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005843773,"about_ca_system_score_gemma":0.0001508806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000814383,"about_ca_topic_score_gemma":0.000009230948,"domain_scores_codex":[0.9986656,0.0002551457,0.0004397546,0.0002677403,0.00004024398,0.0003315598],"domain_scores_gemma":[0.999036,0.0002325262,0.0001149995,0.0003832627,0.0002186279,0.00001465218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007221584,0.0001915432,0.000601744,0.0001710983,0.0002119266,0.000004497142,0.0005748649,0.0003077671,0.9813024,0.0002591105,0.000740885,0.01491201],"study_design_scores_gemma":[0.001514406,0.0002117668,0.000705318,0.0001916666,0.0001288527,0.00004849508,0.0008112352,0.00007802459,0.9694936,0.0000124894,0.0266414,0.0001627853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9546717,0.0429875,0.0008696099,0.0003229824,0.0005104959,0.0003732498,0.00009182655,0.00005443153,0.0001181788],"genre_scores_gemma":[0.9952045,0.001070796,0.00009124113,0.00008916337,0.00002853839,0.0001237147,0.00007640274,0.00002810214,0.003287562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0419167,"threshold_uncertainty_score":0.5962002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01110493161831039,"score_gpt":0.2366183086341058,"score_spread":0.2255133770157954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}