{"id":"W3131831939","doi":"10.1101/2021.02.16.21251687","title":"Lack of Causal Effects or Genetic Correlation between Restless Legs Syndrome and Parkinson’s Disease","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Restless Legs Syndrome Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Parkinson Canada; Westfälische Wilhelms-Universität Münster; Barts Charity; Canada First Research Excellence Fund; Canada Research Chairs; McGill University; Parkinson's UK; Fonds de Recherche du Québec - Santé; Michael J. Fox Foundation for Parkinson's Research","keywords":"Mendelian randomization; Confounding; Parkinson's disease; Correlation; Epidemiology; Disease; Linkage disequilibrium; Heritability; Genetic association; Statistic; Genetic correlation; Medicine; Internal medicine; Statistics; Genetics; Biology; Genetic variation; Allele; Genotype; Genetic variants; Mathematics; Population","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02970482,0.0007872382,0.00155284,0.001026707,0.0003939055,0.001610461,0.001124877,0.00115737,0.006459923],"category_scores_gemma":[0.06179046,0.0004591157,0.003428191,0.001614231,0.001284237,0.0006814185,0.0008260608,0.001103327,0.0003168399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003919476,"about_ca_system_score_gemma":0.001214312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001804095,"about_ca_topic_score_gemma":0.001188152,"domain_scores_codex":[0.9785943,0.0148651,0.00144178,0.003325907,0.00138605,0.0003869123],"domain_scores_gemma":[0.9308555,0.05681447,0.00566778,0.004976872,0.001212002,0.0004734144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01171599,0.0002345044,0.8145105,0.004037661,0.09123665,0.001489967,0.0005479867,0.004342071,0.006122508,0.01068056,0.004078822,0.05100273],"study_design_scores_gemma":[0.005767779,0.003005523,0.7712536,0.001674755,0.1000733,0.003039209,0.0006944045,0.01920348,0.007519249,0.06859846,0.01903148,0.0001386889],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8694901,0.04427015,0.06157079,0.00828659,0.001041929,0.0003058235,0.005533647,0.0006091486,0.008891844],"genre_scores_gemma":[0.9885104,0.00145365,0.007391053,0.0007587622,0.0002064228,0.0001221729,0.0008356404,0.00004738159,0.000674371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02970482,"threshold_uncertainty_score":0.157096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07641645754745856,"score_gpt":0.3608115482081826,"score_spread":0.284395090660724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}