{"id":"W3131835505","doi":"10.1016/j.jaip.2021.02.059","title":"Cluster Analysis of Inflammatory Biomarker Expression in the International Severe Asthma Registry","year":2021,"lang":"en","type":"article","venue":"The Journal of Allergy and Clinical Immunology In Practice","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Coastal Health; Vancouver Coastal Health Research Institute; University of British Columbia","funders":"Efficacy and Mechanism Evaluation Programme; Sanofi Genzyme; Pfizer; AKL Research and Development; Regeneron Pharmaceuticals; Teva Pharmaceutical Industries; Sanofi; Health Technology Assessment Programme; AstraZeneca; Amgen; Mylan; GlaxoSmithKline","keywords":"Medicine; Asthma; Biomarker; Cluster (spacecraft); Internal medicine; Oncology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004883081,0.0003362433,0.0006376982,0.003422084,0.0005848645,0.001108393,0.0006196402,0.0003380864,0.001116359],"category_scores_gemma":[0.009062682,0.0002033471,0.0008074571,0.003601244,0.0003326569,0.0003820391,0.001764952,0.0004868028,0.0003146683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000594193,"about_ca_system_score_gemma":0.001075546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008399277,"about_ca_topic_score_gemma":0.00658071,"domain_scores_codex":[0.9953726,0.001801478,0.0005881657,0.0009947836,0.0007170561,0.000525902],"domain_scores_gemma":[0.9917502,0.001426138,0.003520792,0.001438826,0.001337334,0.0005267109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002134019,0.00001939572,0.9955773,0.00002011231,0.0001237455,0.00004194381,0.0001501718,0.0004951681,0.0002758428,0.000084135,0.0006170762,0.002381749],"study_design_scores_gemma":[0.0000123104,0.00006974438,0.9962584,0.00001440144,0.00006034532,0.000190418,0.0004212499,0.00195439,0.0002197039,0.0001073969,0.0006793039,0.00001235031],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949983,0.0001461384,0.001069908,0.00007297265,0.000009079624,0.00007427429,0.002940302,0.00003459548,0.0006544471],"genre_scores_gemma":[0.993094,0.00004722788,0.001297045,0.00001906763,0.000009269597,0.0001045953,0.005291535,0.00001324284,0.0001241532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008399277,"threshold_uncertainty_score":0.02582449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02396305467888572,"score_gpt":0.3578978944785375,"score_spread":0.3339348397996518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}