{"id":"W3131863295","doi":"10.1038/s41598-021-83265-2","title":"Structural design principles for specific ultra-high affinity interactions between colicins/pyocins and immunity proteins","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; University of Haifa; Azrieli Foundation; Israel Science Foundation; International Development Research Centre","keywords":"Colicin; Immunity; Computational biology; Computer science; Biology; Bioinformatics; Immune system; Immunology; Escherichia coli; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004040768,0.0004856861,0.0004166871,0.0002007096,0.0004140455,0.0007098893,0.0007469801,0.0005398346,0.001685688],"category_scores_gemma":[0.0004023068,0.0005003657,0.0002896377,0.0001316959,0.0005822789,0.0005995024,0.000553981,0.0009603542,0.0004814865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006856093,"about_ca_system_score_gemma":0.000741555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004806412,"about_ca_topic_score_gemma":0.00106931,"domain_scores_codex":[0.9998389,0.00002826756,0.000008718565,0.00002422494,0.00006203245,0.00003784262],"domain_scores_gemma":[0.9999204,0.00002091023,0.00001851841,0.000008888246,0.00001429583,0.00001700209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002790077,0.0003768775,0.001978975,0.0005659026,0.00006406889,0.0006439628,0.0001766714,0.1299132,0.785871,0.06368928,0.0008484662,0.01559265],"study_design_scores_gemma":[0.0006165222,0.001762701,0.003777683,0.00009761888,0.0001214662,0.0009165209,0.0004759101,0.5905204,0.3419727,0.04136205,0.01826355,0.0001128486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8379481,0.001471405,0.1493789,0.0005769557,0.00005522374,0.0003383539,0.0001201891,0.0004128995,0.009697926],"genre_scores_gemma":[0.9410675,0.001124309,0.05570477,0.0001942839,0.000008226093,0.000322463,0.0001236439,0.00008656382,0.001368333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001685688,"threshold_uncertainty_score":0.005639136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06674580612527492,"score_gpt":0.3174082940861944,"score_spread":0.2506624879609194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}