{"id":"W3131891501","doi":"10.1158/1538-7445.sabcs20-ps13-20","title":"Abstract PS13-20: Bringing diarrhea under CONTROL: Dose escalation reduces neratinib-associated diarrhea and improves tolerability in HER2-positive early-stage breast cancer","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; McGill University Health Centre","funders":"","keywords":"Neratinib; Medicine; Loperamide; Tolerability; Diarrhea; Internal medicine; Breast cancer; Oncology; Trastuzumab; Metastatic breast cancer; Gastroenterology; Cancer; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004901651,0.0004109026,0.0008133933,0.0002461376,0.0001493866,0.0004881732,0.0004166655,0.0003239383,0.007756781],"category_scores_gemma":[0.0005514267,0.0001518634,0.0006347035,0.0003600516,0.0002428966,0.0004375554,0.0002548372,0.001327556,0.0006934637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005656168,"about_ca_system_score_gemma":0.0007399578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005380308,"about_ca_topic_score_gemma":0.001413051,"domain_scores_codex":[0.9998443,0.00004632719,0.00001649457,0.00003160325,0.00002224045,0.00003893815],"domain_scores_gemma":[0.9997696,0.00003495902,0.00005810758,0.00002848582,0.00002280764,0.00008603408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3901111,0.03588874,0.007948287,0.00176416,0.001805071,0.0002048141,0.0001827932,0.004721541,0.09749822,0.0004475732,0.01280237,0.4466252],"study_design_scores_gemma":[0.4359456,0.4492726,0.05511307,0.0001443107,0.00168962,0.0007546747,0.0001292443,0.004802491,0.03652766,0.0006745624,0.01487517,0.0000709953],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947802,0.00116161,0.0004208173,0.0002224784,0.0000556222,0.0004943763,0.0007663385,0.0001485048,0.001950055],"genre_scores_gemma":[0.994415,0.0008287221,0.0006995845,0.0003759556,0.00003216395,0.0003297963,0.00132455,0.0000262074,0.001968098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007756781,"threshold_uncertainty_score":0.025949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03933981352638646,"score_gpt":0.3688736865498851,"score_spread":0.3295338730234986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}