{"id":"W3131891501","doi":"10.1158/1538-7445.sabcs20-ps13-20","title":"Abstract PS13-20: Bringing diarrhea under CONTROL: Dose escalation reduces neratinib-associated diarrhea and improves tolerability in HER2-positive early-stage breast cancer","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; McGill University Health Centre","funders":"","keywords":"Neratinib; Medicine; Loperamide; Tolerability; Diarrhea; Internal medicine; Breast cancer; Oncology; Trastuzumab; Metastatic breast cancer; Gastroenterology; Cancer; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001186418,0.0002325657,0.0005204935,0.0002620314,0.0002194188,0.0001974683,0.0001145192,0.00012784,0.0006844634],"category_scores_gemma":[0.0002287205,0.0002194115,0.00009585117,0.0008866959,0.0002260382,0.0002955313,0.0001295109,0.0007959406,0.00000535218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001047896,"about_ca_system_score_gemma":0.0006645286,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01106102,"about_ca_topic_score_gemma":0.00734673,"domain_scores_codex":[0.9971232,0.0002579915,0.0004423577,0.0006900179,0.0007205841,0.0007658192],"domain_scores_gemma":[0.9984769,0.0003553308,0.0001057811,0.0002975226,0.0005120601,0.0002524508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009715467,0.0002432996,0.917877,0.000379925,0.0003323502,0.0002148706,0.001178842,0.0003467614,0.05540906,0.0001337513,0.0008771401,0.02203541],"study_design_scores_gemma":[0.003494269,0.00007425097,0.9894788,0.0004547755,0.00004816714,0.000004566296,0.000458446,0.0006590475,0.004887068,0.00007002249,0.0001751316,0.0001954866],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839126,0.001716375,0.00001497021,0.01213524,0.0002239278,0.0008624957,0.0001646287,0.00005091358,0.000918825],"genre_scores_gemma":[0.9955925,0.0008342362,0.0000221037,0.0003307375,0.0003143494,0.0002613311,0.00004662224,0.00003965309,0.002558463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07160173,"threshold_uncertainty_score":0.9955244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03933981352638646,"score_gpt":0.3688736865498851,"score_spread":0.3295338730234986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}