{"id":"W3131892506","doi":"10.1038/s41467-021-21336-8","title":"Discrete SARS-CoV-2 antibody titers track with functional humoral stability","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Musk Foundation; U.S. Food and Drug Administration; Massachusetts Consortium on Pathogen Readiness; National Cancer Institute; Ragon Institute of MGH, MIT and Harvard; Hamilton Health Sciences Foundation; Bill and Melinda Gates Foundation; National Institute on Drug Abuse; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; National Aeronautics and Space Administration; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Antibody; Immunology; Antibody titer; Immunity; Virology; Biology; Humoral immunity; Immune system; Titer; Antibody-dependent enhancement; Neutralization; Medicine; Virus; Viral replication","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005848224,0.0001892832,0.0002010088,0.0005629272,0.0001610876,0.0005539496,0.0001805666,0.0002822789,0.002672207],"category_scores_gemma":[0.001061835,0.0001012203,0.0001669246,0.0003308039,0.0001960667,0.0003381681,0.0001947819,0.0006873047,0.0006043625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001597362,"about_ca_system_score_gemma":0.0001229873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000633718,"about_ca_topic_score_gemma":0.0005396442,"domain_scores_codex":[0.9997206,0.00004591235,0.00002567264,0.00008468293,0.00006685536,0.00005628262],"domain_scores_gemma":[0.9990698,0.0002127224,0.0002771974,0.0001109435,0.0002255855,0.0001039468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007887597,0.000268364,0.539254,0.0001726263,0.0001237153,0.0002910053,0.0005996604,0.0003938999,0.3997635,0.0004758847,0.0007163988,0.05715234],"study_design_scores_gemma":[0.00001140589,0.001617519,0.940056,0.00001739217,0.00005165967,0.001595762,0.0003202172,0.000888833,0.05231871,0.0002994954,0.002813103,0.000009944409],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928775,0.0007972133,0.002075025,0.00008046011,0.00001613959,0.00003161037,0.00050777,0.00007291308,0.003541447],"genre_scores_gemma":[0.9981697,0.0001076164,0.0004960259,0.00003449193,0.000009016931,0.000008215107,0.0003116956,0.000004680274,0.0008584776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002672207,"threshold_uncertainty_score":0.008939385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07917417045453232,"score_gpt":0.4033384112988941,"score_spread":0.3241642408443618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}