{"id":"W3131955789","doi":"10.2139/ssrn.3787898","title":"Evolution of Kinase Polypharmacology Across HSP90 Drug Discovery","year":2021,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Drug discovery; Hsp90; Drug repositioning; Drug; Biology; Pharmacology; Bioinformatics; Genetics; Heat shock protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001337737,0.0004965674,0.0006437736,0.0009632366,0.0005318875,0.001613494,0.0006638328,0.001115439,0.004796171],"category_scores_gemma":[0.002576518,0.0002855844,0.000535862,0.0007421482,0.0004720299,0.00106242,0.0009041879,0.001488645,0.0009802716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001743978,"about_ca_system_score_gemma":0.0009026582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008207639,"about_ca_topic_score_gemma":0.001296626,"domain_scores_codex":[0.999404,0.0001190188,0.00006003103,0.0001277013,0.0001842218,0.0001051001],"domain_scores_gemma":[0.998988,0.0003395812,0.0002350764,0.0001081984,0.0002033935,0.0001257307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00133925,0.0007974642,0.02898227,0.0003283217,0.0004909165,0.001014889,0.0002188146,0.02768848,0.6853732,0.01910899,0.0009430205,0.2337143],"study_design_scores_gemma":[0.000641447,0.006042457,0.240688,0.0003776186,0.001067813,0.01479923,0.000981266,0.2440318,0.3879116,0.02468591,0.07848023,0.0002926259],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98174,0.001406128,0.005280886,0.0006815639,0.00003188088,0.00005709762,0.0002193389,0.0001132262,0.01046992],"genre_scores_gemma":[0.991832,0.001090436,0.003852239,0.000353,0.00002025919,0.00002497828,0.0003097015,0.00005412878,0.002463451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004796171,"threshold_uncertainty_score":0.0160448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006828843073004207,"score_gpt":0.3028573582118967,"score_spread":0.2960285151388925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}