{"id":"W3132000107","doi":"10.1016/j.molcel.2021.01.038","title":"DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells","year":2021,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Princess Margaret Cancer Centre; University of Toronto; Centre Hospitalier de l’Université de Montréal; University Health Network","funders":"Instituto de Salud Carlos III; Canadian Institutes of Health Research; Terry Fox Research Institute; Ontario Institute for Cancer Research; Fundação de Amparo à Pesquisa do Estado de São Paulo; Natural Sciences and Engineering Research Council of Canada; European Regional Development Fund; Breast Cancer Research Foundation; Princess Margaret Cancer Foundation; European Commission; Canadian Cancer Society; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Albert Einstein Cancer Center","keywords":"Biology; Cytolysis; Cytotoxic T cell; DNA; CD8; Cancer research; Molecular biology; Virology; Cell biology; Immunology; Biochemistry; Immune system; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002510199,0.0004819916,0.0004046236,0.000354688,0.0001631236,0.0003672011,0.0002216935,0.0004323942,0.003681568],"category_scores_gemma":[0.0003010664,0.0001999117,0.0002926934,0.0002102346,0.0002160211,0.0002481953,0.0002783744,0.001453922,0.0006106534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002023931,"about_ca_system_score_gemma":0.0001812462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001864726,"about_ca_topic_score_gemma":0.0004344555,"domain_scores_codex":[0.99968,0.00009591308,0.0000284724,0.00004090414,0.00005218132,0.0001025118],"domain_scores_gemma":[0.9997025,0.0001213727,0.00004634183,0.00004366609,0.00002708659,0.000059001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007169704,0.00009670589,0.0002090049,0.00004735144,0.000008952073,0.00003821389,0.00002074447,0.00007112796,0.9954853,0.00008949823,0.00006122673,0.003154963],"study_design_scores_gemma":[0.00006835482,0.001156818,0.002766126,0.000007505808,0.00002349715,0.00009371561,0.00002555473,0.0003006324,0.9940515,0.00005359457,0.001449583,0.000003136271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930755,0.002577154,0.001379019,0.0001406162,0.00009085913,0.00004644265,0.000189721,0.0001079044,0.002392922],"genre_scores_gemma":[0.99494,0.0007457567,0.001066014,0.0001102879,0.00008472629,0.00005191434,0.0003271816,0.00002302299,0.002651253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003681568,"threshold_uncertainty_score":0.01231611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01049616377431704,"score_gpt":0.2391530267311409,"score_spread":0.2286568629568239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}