{"id":"W3132000107","doi":"10.1016/j.molcel.2021.01.038","title":"DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells","year":2021,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Princess Margaret Cancer Centre; University of Toronto; Centre Hospitalier de l’Université de Montréal; University Health Network","funders":"Instituto de Salud Carlos III; Canadian Institutes of Health Research; Terry Fox Research Institute; Ontario Institute for Cancer Research; Fundação de Amparo à Pesquisa do Estado de São Paulo; Natural Sciences and Engineering Research Council of Canada; European Regional Development Fund; Breast Cancer Research Foundation; Princess Margaret Cancer Foundation; European Commission; Canadian Cancer Society; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Albert Einstein Cancer Center","keywords":"Biology; Cytolysis; Cytotoxic T cell; DNA; CD8; Cancer research; Molecular biology; Virology; Cell biology; Immunology; Biochemistry; Immune system; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001574828,0.0001279927,0.0001394595,0.00004175321,0.0000380537,0.00001959704,0.00006466966,0.0001276724,0.00001399881],"category_scores_gemma":[0.0001083287,0.0001438675,0.00006972,0.0001251222,0.00003696953,0.00000467568,0.0001232685,0.00006931016,0.000002205679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001035092,"about_ca_system_score_gemma":0.0000666658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002916357,"about_ca_topic_score_gemma":0.00000385047,"domain_scores_codex":[0.9990871,0.0001292475,0.0001658179,0.0003123587,0.0001491548,0.000156304],"domain_scores_gemma":[0.999368,0.0000219921,0.000125697,0.0002944297,0.0001107795,0.00007913312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002027274,0.00008090661,0.0006128212,0.00005175895,0.00002104869,0.000008290276,0.00002942805,0.0001843509,0.9945888,0.00001086395,0.0000231243,0.004368341],"study_design_scores_gemma":[0.0004036865,0.00008925685,0.001993056,0.00001162296,0.00002443496,8.674062e-7,0.00002122632,0.0003018347,0.9956731,0.0001155895,0.001222256,0.0001431226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833581,0.00075528,0.01221344,0.00003087304,0.0000482065,0.0001039121,0.000008793429,0.000005232446,0.003476174],"genre_scores_gemma":[0.9971617,0.0001688468,0.002135509,0.0000643068,0.00003836953,0.000004698715,0.0000616278,0.00002199021,0.0003428814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01380368,"threshold_uncertainty_score":0.5866745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01049616377431704,"score_gpt":0.2391530267311409,"score_spread":0.2286568629568239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}