{"id":"W3132054742","doi":"10.2174/1570164618666210223160742","title":"Protein Aggregation and Self Assembly in Health and Disease","year":2021,"lang":"en","type":"article","venue":"Current Proteomics","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Protein aggregation; Protein folding; Folding (DSP implementation); Chemistry; Small molecule; Biophysics; Protein structure; Biochemistry; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001440883,0.00009914798,0.00009341037,0.00002571101,0.0000614874,0.00004563739,0.00004375907,0.00004095971,0.000002219298],"category_scores_gemma":[0.0002100617,0.0001054043,0.00002472171,0.00006256222,0.00002211093,0.000007001647,0.0001160698,0.00007580799,7.982583e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001900235,"about_ca_system_score_gemma":0.0003912173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004151795,"about_ca_topic_score_gemma":0.000006171355,"domain_scores_codex":[0.999223,0.00008373892,0.0001602996,0.0003041271,0.00006737667,0.0001614729],"domain_scores_gemma":[0.9994673,0.000003215517,0.0000660349,0.0001560361,0.00003454208,0.0002728795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003280026,0.0006315254,0.05352428,0.002252965,0.00004094678,0.00002320656,0.0002871024,0.00003195818,0.2279284,0.00276456,0.0004052221,0.7117819],"study_design_scores_gemma":[0.009646306,0.001116962,0.06244293,0.003569914,0.00007210376,0.00007613672,0.0004387739,0.00816962,0.544781,0.01668432,0.3504371,0.002564829],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9265066,0.07094529,0.001186962,0.0007215682,0.00004550249,0.0005623615,0.00001472341,0.000009899499,0.000007031046],"genre_scores_gemma":[0.9806128,0.01514105,0.003579725,0.0002077723,0.0001154719,0.0001527876,0.0001338286,0.00001628883,0.00004027065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.709217,"threshold_uncertainty_score":0.4298263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01288435265518468,"score_gpt":0.2793605773297665,"score_spread":0.2664762246745818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}