{"id":"W3132054742","doi":"10.2174/1570164618666210223160742","title":"Protein Aggregation and Self Assembly in Health and Disease","year":2021,"lang":"en","type":"article","venue":"Current Proteomics","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Protein aggregation; Protein folding; Folding (DSP implementation); Chemistry; Small molecule; Biophysics; Protein structure; Biochemistry; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007034309,0.0003588608,0.0005155344,0.0009115288,0.0003925816,0.001331075,0.0003759508,0.001411616,0.001075619],"category_scores_gemma":[0.0003341916,0.0002223432,0.0001531224,0.0005531824,0.001272608,0.002192571,0.0004427563,0.001012588,0.000516133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005820867,"about_ca_system_score_gemma":0.000387039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005124449,"about_ca_topic_score_gemma":0.0007787858,"domain_scores_codex":[0.9998643,0.00003492084,0.00001538418,0.00002735881,0.00003461361,0.00002342262],"domain_scores_gemma":[0.9997543,0.00005901424,0.00003483561,0.00001744794,0.0000575556,0.0000769668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001757482,0.0004853227,0.008935992,0.003266257,0.0001911678,0.001857909,0.001286401,0.00153462,0.3252401,0.1018236,0.04085,0.512771],"study_design_scores_gemma":[0.0001436955,0.00137777,0.07555557,0.000698127,0.0002425943,0.006247318,0.002589828,0.01136792,0.1232274,0.2528991,0.5254738,0.0001769878],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.09446368,0.8644518,0.007869353,0.01971325,0.002140177,0.0000344938,0.0001644499,0.0001844816,0.01097829],"genre_scores_gemma":[0.5798418,0.3929749,0.003874436,0.004027848,0.004752766,0.00003756496,0.0003075388,0.00002280021,0.0141603],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001411616,"threshold_uncertainty_score":0.004223347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01288435265518468,"score_gpt":0.2793605773297665,"score_spread":0.2664762246745818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}