{"id":"W3132162154","doi":"10.1016/j.bpj.2020.11.1449","title":"Modelling the Multifarious Conformations of the Intrinsically Disordered Protein 4E-BP2 with sm-FRET, SAXS &amp; PRE Restraints","year":2021,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Small-angle X-ray scattering; Radius of gyration; Intrinsically disordered proteins; Chemistry; Förster resonance energy transfer; Crystallography; Conformational isomerism; Single-molecule FRET; Conformational ensembles; Scattering; Molecule; Molecular dynamics; Physics; Fluorescence; Computational chemistry; Polymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003638102,0.0005361512,0.0005042155,0.0002510187,0.0006104448,0.0007288952,0.00100134,0.0009392492,0.002960393],"category_scores_gemma":[0.0008004332,0.0004348603,0.0004345313,0.000554982,0.0005148388,0.001004853,0.0004492688,0.001035846,0.0003134365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001094989,"about_ca_system_score_gemma":0.001136472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01072821,"about_ca_topic_score_gemma":0.0130338,"domain_scores_codex":[0.9998544,0.00002583138,0.000007539084,0.00002954532,0.00003597197,0.00004670357],"domain_scores_gemma":[0.9997914,0.00009539274,0.00002737686,0.0000269643,0.00002199558,0.00003671375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0003898957,0.0001926581,0.004253854,0.0001491297,0.00006879532,0.0006132595,0.0002850687,0.941155,0.04087111,0.006386281,0.0007309346,0.004904025],"study_design_scores_gemma":[0.00004781442,0.00007297834,0.002685191,0.00001353686,0.00001585388,0.00007546703,0.0001004905,0.9845105,0.009791731,0.001721108,0.0009393748,0.00002603766],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823436,0.0002052635,0.01331051,0.0001918866,0.00001205769,0.00002099109,0.0006556621,0.0001911065,0.00306891],"genre_scores_gemma":[0.9899868,0.0002188488,0.008063755,0.00002425657,0.000003268784,0.0000400733,0.0006894391,0.00007243726,0.0009009935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01072821,"threshold_uncertainty_score":0.02133155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01400293054655477,"score_gpt":0.2236940957888534,"score_spread":0.2096911652422986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}