{"id":"W3132165990","doi":"10.3390/toxins13020138","title":"Extracts Prepared from a Canadian Toxic Plant Induce Light-Dependent Perinuclear Vacuoles in Human Cells","year":2021,"lang":"en","type":"article","venue":"Toxins","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation","keywords":"Vacuole; Vacuolization; Biology; Cell biology; Cytoplasm; Lamin; Autophagy; Plant cell; Nucleus; Cell nucleus; Biochemistry; Apoptosis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001189429,0.0002737371,0.000137346,0.0003160492,0.0004831124,0.0002398746,0.0001237317,0.0001851274,0.002047425],"category_scores_gemma":[0.0001157573,0.0001013249,0.0001515693,0.0002969231,0.00021,0.00007098602,0.0001996815,0.000280806,0.0003075636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005819275,"about_ca_system_score_gemma":0.0005239599,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03695795,"about_ca_topic_score_gemma":0.1057057,"domain_scores_codex":[0.9998811,0.00001550569,0.000005358419,0.0000237358,0.00004614674,0.00002812006],"domain_scores_gemma":[0.9999272,0.00001778047,0.00001013369,0.00000955876,0.00002443153,0.00001093554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001164608,0.00001340756,0.0005302428,0.00005443501,0.0000108733,0.00009872496,0.00007235357,0.0000288734,0.9971615,0.0000788254,0.0001272702,0.001707133],"study_design_scores_gemma":[0.00002457104,0.0003209442,0.04145746,0.00002029874,0.00004681997,0.0008912615,0.0002391814,0.0002456717,0.9431018,0.00006574449,0.01357548,0.00001071517],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857616,0.002988326,0.003048926,0.0002124877,0.00002887102,0.00009202303,0.0009339884,0.0001008969,0.006832695],"genre_scores_gemma":[0.9864114,0.001782733,0.003537585,0.0001076735,0.000007599135,0.00003483495,0.001828989,0.00001881364,0.006270302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.963042,"threshold_uncertainty_score":0.07348567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00794921522357027,"score_gpt":0.2124885025760842,"score_spread":0.2045392873525139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}