{"id":"W3132191236","doi":"10.3390/antiox10020292","title":"Insulin–Mimetic Dihydroxanthyletin-Type Coumarins from Angelica decursiva with Protein Tyrosine Phosphatase 1B and α-Glucosidase Inhibitory Activities and Docking Studies of Their Molecular Mechanisms","year":2021,"lang":"en","type":"article","venue":"Antioxidants","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Alberta Children's Hospital; University of Calgary","funders":"Pusan National University","keywords":"Chemistry; Enzyme; Docking (animal); Peroxynitrite; Biochemistry; Non-competitive inhibition; Coumarin; Protein tyrosine phosphatase; Active site; Stereochemistry; Superoxide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001386852,0.0003324223,0.0004228716,0.00005191079,0.0001321367,0.00004679721,0.0001290757,0.0001249729,0.000008400986],"category_scores_gemma":[0.000215038,0.0002868597,0.00004901433,0.0001767133,0.0003825478,0.00002436463,0.0004254194,0.0001203417,0.000001057647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000131547,"about_ca_system_score_gemma":0.0001141368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00010059,"about_ca_topic_score_gemma":0.00007066942,"domain_scores_codex":[0.9984677,0.0001117032,0.0002852827,0.0006245383,0.0002096011,0.0003011766],"domain_scores_gemma":[0.9989492,0.00005147274,0.0002045894,0.0004718884,0.0002124666,0.0001103405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003065519,0.0001941314,0.0008469388,0.0001267416,0.0002915505,0.0001188796,0.0001115343,0.00000384619,0.994805,0.0007926218,0.00007499823,0.002327153],"study_design_scores_gemma":[0.001444822,0.000566783,0.001770391,0.0004274228,0.00009235988,0.00004323689,0.0004543384,0.00001325968,0.9936301,0.0008591877,0.0003552694,0.0003427934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.861687,0.1369881,0.0004420063,0.00009053404,0.00005702677,0.0003375631,0.0003636792,0.00001830527,0.000015732],"genre_scores_gemma":[0.9923101,0.003894805,0.003212865,0.0001723414,0.00004980357,0.0000358816,0.0002530888,0.00004624375,0.00002487212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1330933,"threshold_uncertainty_score":0.9999583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01179591708666158,"score_gpt":0.2447028762048981,"score_spread":0.2329069591182365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}