{"id":"W3132191236","doi":"10.3390/antiox10020292","title":"Insulin–Mimetic Dihydroxanthyletin-Type Coumarins from Angelica decursiva with Protein Tyrosine Phosphatase 1B and α-Glucosidase Inhibitory Activities and Docking Studies of Their Molecular Mechanisms","year":2021,"lang":"en","type":"article","venue":"Antioxidants","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Alberta Children's Hospital; University of Calgary","funders":"Pusan National University","keywords":"Chemistry; Enzyme; Docking (animal); Peroxynitrite; Biochemistry; Non-competitive inhibition; Coumarin; Protein tyrosine phosphatase; Active site; Stereochemistry; Superoxide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006337505,0.0002965276,0.0002494669,0.0001152305,0.00008217549,0.0001816521,0.0002178356,0.0001702109,0.0009580384],"category_scores_gemma":[0.00007453319,0.0001027631,0.0003263642,0.0001457318,0.0001021209,0.0002046202,0.0001250384,0.0003746892,0.0001859179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002206381,"about_ca_system_score_gemma":0.0001080069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007756104,"about_ca_topic_score_gemma":0.0009917652,"domain_scores_codex":[0.9999732,0.000004126696,0.000001228732,0.000006380687,0.000008209318,0.000006902841],"domain_scores_gemma":[0.9999802,0.000004310726,0.000007076136,0.000001389494,0.000002687697,0.000004261126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006990072,0.000224553,0.001257026,0.0004239119,0.00009545594,0.0003252076,0.00003752642,0.01411963,0.969062,0.001321358,0.0003862838,0.01204805],"study_design_scores_gemma":[0.000303226,0.001693405,0.003971163,0.00002718255,0.000169216,0.0004450382,0.00005565451,0.05689708,0.9256679,0.0004646469,0.01027163,0.00003390328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987866,0.005987349,0.003441711,0.0001539915,0.00002190542,0.00002666112,0.0003028403,0.00007446492,0.002125103],"genre_scores_gemma":[0.9943336,0.002208514,0.001691126,0.00003159315,0.000004336572,0.00001400406,0.0004110513,0.00000812072,0.001297645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009580384,"threshold_uncertainty_score":0.003204942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01179591708666158,"score_gpt":0.2447028762048981,"score_spread":0.2329069591182365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}