{"id":"W3132205831","doi":"10.1200/jco.20.01366","title":"ROBUST: A Phase III Study of Lenalidomide Plus R-CHOP Versus Placebo Plus R-CHOP in Previously Untreated Patients With ABC-Type Diffuse Large B-Cell Lymphoma","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":270,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC","funders":"Chugai Pharmaceutical; MorphoSys; Kite Pharma; Incyte; Eisai; Karyopharm Therapeutics; Genentech; Celgene; Daiichi Sankyo Europe; Bristol-Myers Squibb","keywords":"Medicine; CHOP; Lenalidomide; Internal medicine; International Prognostic Index; Placebo; Diffuse large B-cell lymphoma; Vincristine; Gastroenterology; Neutropenia; Clinical endpoint; Rituximab; Surgery; Lymphoma; Oncology; Cyclophosphamide; Chemotherapy; Pathology; Clinical trial; Multiple myeloma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001473346,0.0003442204,0.002997529,0.0002318197,0.00005979958,0.00001711765,0.0002082681,0.0004040032,0.0001577044],"category_scores_gemma":[0.002374648,0.0002292408,0.0004181626,0.0005155094,0.0001300281,0.0001435628,0.0001280178,0.0005045303,0.00001613676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00125312,"about_ca_system_score_gemma":0.004510611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001840372,"about_ca_topic_score_gemma":0.001034314,"domain_scores_codex":[0.9941854,0.0008991788,0.003211193,0.0004549873,0.0007533084,0.0004958778],"domain_scores_gemma":[0.9924062,0.003151086,0.00225756,0.0004729684,0.001141762,0.0005704044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3042631,0.2760313,0.3813756,0.00008082706,0.002287667,0.01369612,0.001503731,0.0002667637,0.00001605025,0.00001288818,0.001526897,0.01893913],"study_design_scores_gemma":[0.7236745,0.06862385,0.2009778,0.0002855318,0.001948054,0.0001134215,0.001143689,0.0002103815,0.00009316567,0.00000473212,0.002745562,0.0001793083],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956602,0.0007547352,0.0000109558,0.000447102,0.00103744,0.00108153,0.0000127343,0.00001261431,0.0009826729],"genre_scores_gemma":[0.9976996,0.0007438389,0.0004874498,0.0004641742,0.0002593318,0.00002418995,0.00002322694,0.00003888729,0.000259289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4194114,"threshold_uncertainty_score":0.9348167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09420162739570512,"score_gpt":0.4095635778351286,"score_spread":0.3153619504394235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}