{"id":"W3132205831","doi":"10.1200/jco.20.01366","title":"ROBUST: A Phase III Study of Lenalidomide Plus R-CHOP Versus Placebo Plus R-CHOP in Previously Untreated Patients With ABC-Type Diffuse Large B-Cell Lymphoma","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":270,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC","funders":"Chugai Pharmaceutical; MorphoSys; Kite Pharma; Incyte; Eisai; Karyopharm Therapeutics; Genentech; Celgene; Daiichi Sankyo Europe; Bristol-Myers Squibb","keywords":"Medicine; CHOP; Lenalidomide; Internal medicine; International Prognostic Index; Placebo; Diffuse large B-cell lymphoma; Vincristine; Gastroenterology; Neutropenia; Clinical endpoint; Rituximab; Surgery; Lymphoma; Oncology; Cyclophosphamide; Chemotherapy; Pathology; Clinical trial; Multiple myeloma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003171657,0.001867635,0.00309023,0.0004854357,0.0004322664,0.001164627,0.001318883,0.001173459,0.003467648],"category_scores_gemma":[0.00165525,0.0008166077,0.001739613,0.0004470499,0.001617089,0.001075416,0.0005622678,0.00269539,0.0008314569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00085339,"about_ca_system_score_gemma":0.001381096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005494609,"about_ca_topic_score_gemma":0.001191251,"domain_scores_codex":[0.9989572,0.0006418668,0.00005959006,0.0001584211,0.00007759093,0.0001053034],"domain_scores_gemma":[0.9989911,0.0001936153,0.0002718303,0.0001226744,0.00006473084,0.0003559514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9326381,0.03107107,0.001604045,0.0005516967,0.001284303,0.00006345449,0.00007985572,0.0007760692,0.00832727,0.0001376227,0.0007742182,0.02269212],"study_design_scores_gemma":[0.7374282,0.2563447,0.003153013,0.0000257102,0.0006036239,0.00006294073,0.00003100919,0.0006035165,0.0008055064,0.0001656895,0.0007525002,0.00002346172],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872543,0.003804994,0.0009076291,0.0004344801,0.0002853752,0.004695783,0.001000396,0.0001369367,0.001480082],"genre_scores_gemma":[0.9860064,0.001954872,0.003172896,0.0009382198,0.0003941987,0.004785767,0.001327333,0.00003263937,0.001387645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003467648,"threshold_uncertainty_score":0.01677352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09420162739570512,"score_gpt":0.4095635778351286,"score_spread":0.3153619504394235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}