{"id":"W3132220577","doi":"10.1016/j.ibmb.2021.103556","title":"Systemic and mitochondrial effects of metabolic inflexibility induced by high fat diet in Drosophila melanogaster","year":2021,"lang":"en","type":"article","venue":"Insect Biochemistry and Molecular Biology","topic":"Neurobiology and Insect Physiology Research","field":"Neuroscience","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Moncton","funders":"Natural Sciences and Engineering Research Council of Canada; New Brunswick Innovation Foundation; Canada Foundation for Innovation; Université de Moncton","keywords":"Drosophila melanogaster; Biology; Mitochondrion; Proline dehydrogenase; Metabolic pathway; Mitochondrial ROS; Reactive oxygen species; Metabolism; Endocrinology; Internal medicine; Biochemistry; Cell biology; Dehydrogenase; Enzyme; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009778694,0.0002096553,0.0004471818,0.00005845135,0.00006020263,0.00001076697,0.000174184,0.0004142513,0.00001397404],"category_scores_gemma":[0.0009116515,0.0001898687,0.00005570516,0.0002149841,0.0005636922,0.0000362082,0.0002693318,0.0003745325,0.000002395934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008264099,"about_ca_system_score_gemma":0.00006226706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003470717,"about_ca_topic_score_gemma":0.000002203935,"domain_scores_codex":[0.9978583,0.0006849683,0.0002952994,0.000762044,0.00006390023,0.000335456],"domain_scores_gemma":[0.9990537,0.0003780336,0.00009298483,0.0003454676,0.00004121265,0.00008858785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002939663,0.00009968337,0.001167043,0.0001947951,0.00001837385,0.00009157197,0.0000359471,2.167897e-7,0.9972485,0.0007139337,0.00001448819,0.0001214761],"study_design_scores_gemma":[0.001115674,0.0003477538,0.001540539,0.00003880773,0.00001335076,0.0001513732,0.000006871934,0.000002740794,0.9949822,0.001609445,0.00003755031,0.0001536546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973127,0.001982716,0.0000126023,0.0001200078,0.0001913288,0.0002126014,0.00004648294,0.00001458638,0.000106952],"genre_scores_gemma":[0.9990621,0.0002794801,0.00002003159,0.0004774311,0.00004286572,0.00003878362,0.00003237465,0.00001028713,0.0000366109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002266266,"threshold_uncertainty_score":0.7742619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0130470463104449,"score_gpt":0.274335441773328,"score_spread":0.2612883954628831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}