{"id":"W3132239282","doi":"10.1016/s2468-1253(21)00007-8","title":"The effect of a microbial ecosystem therapeutic (MET-2) on recurrent Clostridioides difficile infection: a phase 1, open-label, single-group trial","year":2021,"lang":"en","type":"article","venue":"The Lancet. Gastroenterology & hepatology","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University; McMaster University; University of Guelph; University of Alberta","funders":"Canadian Institutes of Health Research; University of Alberta","keywords":"Clostridioides; Tolerability; Nausea; Medicine; Vomiting; Internal medicine; Adverse effect; Antibiotics; Abdominal pain; Quality of life (healthcare); Gastroenterology; Surgery; Microbiology; Biology; Nursing","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001636371,0.00056621,0.001975339,0.0001907994,0.0005472268,0.0001210559,0.0008718869,0.0003591937,0.0001303012],"category_scores_gemma":[0.0003679645,0.0003517248,0.000395691,0.0005169464,0.0006367916,0.00006042466,0.0005879897,0.001342425,0.00007205072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003674451,"about_ca_system_score_gemma":0.0002836912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009024324,"about_ca_topic_score_gemma":0.001614717,"domain_scores_codex":[0.9930629,0.002950152,0.001157003,0.0009259344,0.0004924543,0.001411548],"domain_scores_gemma":[0.9958313,0.001634295,0.0005028844,0.001529281,0.0002778622,0.0002244512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.613728,0.008339335,0.0430171,0.0004738226,0.002362386,0.0007384927,0.0001542584,0.000009728191,0.2664076,0.0003557412,0.01478338,0.0496301],"study_design_scores_gemma":[0.4377026,0.2101789,0.001281807,0.0005331291,0.001651957,0.00472264,0.000145011,0.001055052,0.2391369,0.00007512542,0.1029356,0.0005813379],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879974,0.001122241,0.0001059269,0.005394381,0.002278831,0.002486785,0.0001399385,0.00008197928,0.0003925008],"genre_scores_gemma":[0.9961622,0.0006092379,0.0000292907,0.0009597146,0.001407414,0.0004927331,0.0001336249,0.00006464474,0.0001411245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2018396,"threshold_uncertainty_score":0.9998935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05859342007565647,"score_gpt":0.3498645620717677,"score_spread":0.2912711419961113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}