{"id":"W3132239282","doi":"10.1016/s2468-1253(21)00007-8","title":"The effect of a microbial ecosystem therapeutic (MET-2) on recurrent Clostridioides difficile infection: a phase 1, open-label, single-group trial","year":2021,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University; McMaster University; University of Guelph; University of Alberta","funders":"Canadian Institutes of Health Research; University of Alberta","keywords":"Clostridioides; Tolerability; Nausea; Medicine; Vomiting; Internal medicine; Adverse effect; Antibiotics; Abdominal pain; Quality of life (healthcare); Gastroenterology; Surgery; Microbiology; Biology; Nursing","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009512346,0.001179462,0.001898108,0.0002653492,0.0003202641,0.0008584248,0.0006869602,0.00215164,0.005073816],"category_scores_gemma":[0.001090591,0.0003243264,0.001670316,0.000264824,0.0006011649,0.0008588678,0.00031448,0.002857436,0.0007541864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005770227,"about_ca_system_score_gemma":0.0007815307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006018454,"about_ca_topic_score_gemma":0.001403678,"domain_scores_codex":[0.9996521,0.0001631867,0.00001808792,0.00005921668,0.00002849682,0.00007886915],"domain_scores_gemma":[0.999503,0.0001550381,0.00009368386,0.00003166839,0.00003206917,0.0001845208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9145381,0.005100949,0.0006363829,0.001486557,0.001241623,0.0001146809,0.00006283532,0.0004777469,0.007696141,0.0002353312,0.002221269,0.06618842],"study_design_scores_gemma":[0.864992,0.1283327,0.00271732,0.0001381217,0.0006216032,0.0001576702,0.0000420813,0.0005127637,0.0009293332,0.0002390408,0.001291335,0.00002603783],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754531,0.01744587,0.0006091304,0.00199469,0.000676695,0.0007618903,0.0007891846,0.0001331977,0.002136257],"genre_scores_gemma":[0.9873233,0.005185349,0.001372772,0.001530757,0.0004287317,0.001017562,0.0008622537,0.00002230417,0.002256975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005073816,"threshold_uncertainty_score":0.01697361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05859342007565647,"score_gpt":0.3498645620717677,"score_spread":0.2912711419961113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}