{"id":"W3132264975","doi":"10.1016/j.esmoop.2021.100057","title":"Tumor mutational burden and immune infiltrates in renal cell carcinoma and matched brain metastases","year":2021,"lang":"en","type":"article","venue":"ESMO Open","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Merck Sharp and Dohme; Ipsen; Medizinische Universität Wien; Universität Wien; Roche; AbbVie; GlaxoSmithKline; Merck; Bristol-Myers Squibb; AstraZeneca; Daiichi-Sankyo; CMC Microsystems; Amgen; Pfizer; Exelixis","keywords":"Renal cell carcinoma; Tumor-infiltrating lymphocytes; Medicine; Brain metastasis; FOXP3; CD8; Pathology; Tumor microenvironment; Immunohistochemistry; Lung; Oncology; Metastasis; Immune system; Internal medicine; Cancer; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002844013,0.0001302407,0.0002712684,0.0008628072,0.0001861187,0.0002608884,0.0001491068,0.0002410091,0.001123085],"category_scores_gemma":[0.00131214,0.0001358971,0.00009541919,0.0003251669,0.0002210451,0.0001457923,0.0002801618,0.0001990922,0.0002498373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002426651,"about_ca_system_score_gemma":0.0001513204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001372294,"about_ca_topic_score_gemma":0.001496459,"domain_scores_codex":[0.9997606,0.0000445227,0.00002303156,0.00007768741,0.00006295514,0.00003132348],"domain_scores_gemma":[0.999385,0.0001633159,0.0002204712,0.00004733165,0.00005968601,0.0001241304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001494331,0.00005996734,0.9453608,0.00005520443,0.00006583067,0.0008258783,0.0001578828,0.0001821851,0.04675258,0.0000427634,0.00007016063,0.004932408],"study_design_scores_gemma":[0.0000113863,0.000268911,0.9930041,0.000004521404,0.0000286097,0.00291137,0.00008485727,0.0003574262,0.003143809,0.00003017518,0.0001518553,0.000002919934],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994728,0.0002351364,0.00008553672,0.000003668383,0.000001292133,0.000002985322,0.0000546958,0.000003104268,0.0001408702],"genre_scores_gemma":[0.9997572,0.00004460861,0.00006495747,0.000002703066,0.000001797895,0.000003126251,0.00009217724,0.000001612456,0.00003177519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001372294,"threshold_uncertainty_score":0.00375706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01946588835638019,"score_gpt":0.2860749971873176,"score_spread":0.2666091088309374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}