{"id":"W3132319387","doi":"10.1158/1538-7445.sabcs20-ps11-11","title":"Abstract PS11-11: Targeted safety events from a phase I/Ib study evaluating GDC-0077 alone and in combination with endocrine therapy (ET) ± palbociclib (palbo) in patients (pts) with <i>PIK3CA</i>-mutant (mut), hormone receptor-positive/HER2-negative metastatic breast cancer (HR+/HER2- mBC)","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Rash; Neutropenia; Internal medicine; Fulvestrant; Adverse effect; Dysgeusia; Gastroenterology; Letrozole; Maculopapular rash; Surgery; Breast cancer; Toxicity; Cancer; Estrogen receptor; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001584329,0.001388431,0.001441789,0.0004578982,0.0003981967,0.001124694,0.0007480418,0.0009086927,0.009637151],"category_scores_gemma":[0.001055591,0.0003876823,0.001556761,0.0005385178,0.0008485698,0.0005873358,0.0003749645,0.0031192,0.001398467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0014595,"about_ca_system_score_gemma":0.003016504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001386976,"about_ca_topic_score_gemma":0.00437161,"domain_scores_codex":[0.9993672,0.0003195989,0.00003673066,0.00009566303,0.00008756242,0.00009337004],"domain_scores_gemma":[0.9990458,0.0001765359,0.0002165826,0.00006280995,0.00007263603,0.0004255845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7738435,0.03135061,0.009143875,0.001890861,0.002701615,0.0003613909,0.0001936616,0.005471449,0.04513867,0.0005517921,0.01324046,0.116112],"study_design_scores_gemma":[0.478091,0.472372,0.0220244,0.0001280023,0.002069345,0.000511787,0.0001032658,0.00159762,0.01090048,0.0004676856,0.0116833,0.00005118905],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9697066,0.003138296,0.001363154,0.0008634463,0.000144857,0.005591211,0.01097826,0.0002697271,0.00794452],"genre_scores_gemma":[0.9702083,0.003056054,0.001551485,0.001519446,0.0001621973,0.003487787,0.01202438,0.00006870318,0.007921615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009637151,"threshold_uncertainty_score":0.0322395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0498008099973835,"score_gpt":0.4119863499116258,"score_spread":0.3621855399142423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}