{"id":"W3132319387","doi":"10.1158/1538-7445.sabcs20-ps11-11","title":"Abstract PS11-11: Targeted safety events from a phase I/Ib study evaluating GDC-0077 alone and in combination with endocrine therapy (ET) ± palbociclib (palbo) in patients (pts) with <i>PIK3CA</i>-mutant (mut), hormone receptor-positive/HER2-negative metastatic breast cancer (HR+/HER2- mBC)","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Rash; Neutropenia; Internal medicine; Fulvestrant; Adverse effect; Dysgeusia; Gastroenterology; Letrozole; Maculopapular rash; Surgery; Breast cancer; Toxicity; Cancer; Estrogen receptor; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001435588,0.0006205143,0.001151315,0.000487326,0.0002584989,0.00008621193,0.0002582633,0.00009681586,0.0009011388],"category_scores_gemma":[0.0001975066,0.0004924481,0.00006604809,0.002167414,0.0003804192,0.0006366501,0.0001571535,0.001315306,0.000006541291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002139312,"about_ca_system_score_gemma":0.001541759,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.02215013,"about_ca_topic_score_gemma":0.02146038,"domain_scores_codex":[0.9929256,0.001384676,0.000871784,0.001378637,0.002318808,0.001120516],"domain_scores_gemma":[0.9961203,0.0007646161,0.0003638902,0.0006145083,0.001772464,0.0003642268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.09088978,0.01512041,0.6192275,0.0002234868,0.001758329,0.0007950864,0.01747043,0.0006240062,0.111768,0.00001087218,0.00005532421,0.1420567],"study_design_scores_gemma":[0.09851531,0.004776338,0.8690451,0.001789144,0.0001079415,0.00002391682,0.005301229,0.0001425742,0.01950691,0.0001559506,0.00009505027,0.0005405289],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887398,0.003437529,0.00005826656,0.002095015,0.0000789691,0.004424558,0.001071489,0.00005100799,0.00004333816],"genre_scores_gemma":[0.9939315,0.00219143,0.0009351705,0.0002462305,0.00009605003,0.001871818,0.0004716849,0.0001626128,0.00009351007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2498176,"threshold_uncertainty_score":0.9997527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0498008099973835,"score_gpt":0.4119863499116258,"score_spread":0.3621855399142423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}