{"id":"W3132336966","doi":"10.1038/s41598-021-84058-3","title":"Adipose-derived mesenchymal stem cells differentiate into heterogeneous cancer-associated fibroblasts in a stroma-rich xenograft model","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; Astellas Pharma; Astellas Foundation for Research on Metabolic Disorders; Japan Agency for Medical Research and Development","keywords":"Stroma; Stromal cell; Mesenchymal stem cell; Adipose tissue; Cancer research; Biology; Cancer-Associated Fibroblasts; Tumor microenvironment; Cancer stem cell; Stem cell; Tumor progression; Pathology; Cancer; Cell biology; Medicine; Immunology; Endocrinology; Immunohistochemistry; Tumor cells; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004018976,0.000411134,0.0003316354,0.0005929419,0.000145008,0.0002931324,0.0002076935,0.0003180914,0.001024018],"category_scores_gemma":[0.0001011207,0.000180516,0.000354533,0.0003100235,0.0002148048,0.0003219177,0.0001901771,0.0008705943,0.0003622418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001477007,"about_ca_system_score_gemma":0.0002407005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004258702,"about_ca_topic_score_gemma":0.0007613291,"domain_scores_codex":[0.9997744,0.00003742466,0.00002972958,0.00005434284,0.00007396287,0.00003018828],"domain_scores_gemma":[0.9997738,0.00003403629,0.00006209061,0.00005219636,0.00001623913,0.00006164298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002724476,0.0002015479,0.0003654061,0.00005217691,0.00001176212,0.0001410933,0.0000437123,0.0003278564,0.9958088,0.0004216071,0.00009638849,0.002257238],"study_design_scores_gemma":[0.00009553383,0.001575171,0.003169789,0.00001760846,0.00005099746,0.0006355789,0.00008010778,0.005798942,0.982361,0.0002030129,0.00600226,0.00001017045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799107,0.0009360333,0.01546709,0.0001297059,0.00008176652,0.0001564522,0.0008732506,0.0002464338,0.002198559],"genre_scores_gemma":[0.9814883,0.00117326,0.01191715,0.00007596412,0.00002294024,0.0001904661,0.001070141,0.00004607738,0.004015616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001024018,"threshold_uncertainty_score":0.003425658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03050171336844715,"score_gpt":0.3114377443946872,"score_spread":0.2809360310262401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}