{"id":"W3132362554","doi":"10.1016/j.bpj.2020.11.1090","title":"Structural Insights into the Diamide Modulation of Ryanodine Receptor","year":2021,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Insect and Pesticide Research","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Ryanodine receptor; Allosteric regulation; Mutagenesis; Binding site; Biology; Neonicotinoid; Pink bollworm; Biophysics; Chemistry; Mutant; Biochemistry; Receptor; Pesticide; Ecology; Imidacloprid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001664927,0.0002637264,0.0002707668,0.00007750203,0.0002868899,0.0002808711,0.0005213666,0.0003773666,0.001908874],"category_scores_gemma":[0.0001466574,0.0001474849,0.0001972168,0.00006108634,0.0003075894,0.0005321288,0.0002481414,0.001032634,0.000483975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002667723,"about_ca_system_score_gemma":0.0002326491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000346803,"about_ca_topic_score_gemma":0.0003746967,"domain_scores_codex":[0.9999404,0.000007960226,0.000003796733,0.00001490633,0.00001813923,0.00001482499],"domain_scores_gemma":[0.9999473,0.00001435729,0.00001253621,0.000004251236,0.00000711435,0.00001442901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002713556,0.00005968502,0.0002853445,0.0001636065,0.00001835239,0.0008136441,0.00007934098,0.002207876,0.9855124,0.00523939,0.0006213,0.004727608],"study_design_scores_gemma":[0.0002151961,0.0007692482,0.007009805,0.00005357667,0.0000791097,0.002522869,0.000576888,0.04877252,0.9005478,0.01013759,0.02924565,0.00006980974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9693962,0.004698784,0.01516337,0.002350687,0.000250631,0.00003014699,0.0002527464,0.0002126433,0.007644818],"genre_scores_gemma":[0.9924828,0.002662467,0.002440068,0.0003049264,0.00004627086,0.00001049908,0.0002670371,0.00001501125,0.001770937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001908874,"threshold_uncertainty_score":0.006385803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02721367731954521,"score_gpt":0.2606394383396871,"score_spread":0.2334257610201419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}