{"id":"W3132398958","doi":"10.1002/ana.26090","title":"Investigation of Autosomal Genetic Sex Differences in Parkinson's Disease","year":2021,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Environmental Health Sciences; Medical Research Council; Parkinson's UK; National Institute of Neurological Disorders and Stroke; Bundesministerium für Bildung und Forschung; National Institute on Aging; National Institute for Health and Care Research; Institute of Genetics; Barts Charity; Canada First Research Excellence Fund; American Parkinson Disease Association; Consortium canadien en neurodégénérescence associée au vieillissement; Agence Nationale de la Recherche; Wellcome Trust; Helsingin ja Uudenmaan Sairaanhoitopiiri; Helsingin Yliopisto; EU Joint Programme – Neurodegenerative Disease Research; Michael J. Fox Foundation for Parkinson's Research; National Cancer Institute; U.S. Department of Defense; Itä-Suomen Yliopisto; Rosetrees Trust; National Institutes of Health; U.S. Department of Health and Human Services; McGill University","keywords":"Genome-wide association study; Genetic architecture; Disease; Heritability; Autosome; Etiology; Biology; Genetic association; Parkinson's disease; Biobank; Genetics; Genetic variation; Medicine; Internal medicine; Single-nucleotide polymorphism; Genotype; Quantitative trait locus; X chromosome; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004619048,0.0008023045,0.001044142,0.001283261,0.0003906433,0.001148466,0.0007509835,0.0006720338,0.002421882],"category_scores_gemma":[0.008154139,0.0002952064,0.003700807,0.002040315,0.0004686181,0.0004465522,0.00066749,0.0006353102,0.0001472377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002912145,"about_ca_system_score_gemma":0.0004079537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002460368,"about_ca_topic_score_gemma":0.002774549,"domain_scores_codex":[0.9974202,0.00123304,0.0002189035,0.0006975959,0.0003151423,0.0001151765],"domain_scores_gemma":[0.9939669,0.004035287,0.001094026,0.0004564509,0.0002982823,0.0001489863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001889222,0.00003459227,0.9176314,0.001485792,0.04102893,0.0006331393,0.0002220592,0.0007788188,0.00193967,0.0008793307,0.0008348568,0.03264215],"study_design_scores_gemma":[0.000246749,0.0005868322,0.9532703,0.0007128968,0.03270034,0.001659562,0.0002489225,0.001830912,0.001117959,0.00237302,0.005225353,0.00002724474],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8437818,0.1430503,0.0051811,0.001462577,0.0003006373,0.00005613919,0.003565322,0.00007618237,0.002525946],"genre_scores_gemma":[0.9858828,0.01065814,0.001440702,0.0004147067,0.000134359,0.00003880454,0.0009488373,0.00002563199,0.0004559736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004619048,"threshold_uncertainty_score":0.02442813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06701392583429026,"score_gpt":0.2943978093418123,"score_spread":0.227383883507522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}