{"id":"W3132399336","doi":"10.1016/j.clcc.2021.02.003","title":"The Landscape of PIK3CA Mutations in Colorectal Cancer","year":2021,"lang":"en","type":"article","venue":"Clinical Colorectal Cancer","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"NOSM University; Sault Area Hospital","funders":"","keywords":"Colorectal cancer; Medicine; P110α; Cancer research; Mutation; Cancer; Mouse model of colorectal and intestinal cancer; Wnt signaling pathway; Targeted therapy; Oncology; Disease; Gene; Internal medicine; Biology; Genetics; Protein subunit","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003210834,0.0001601859,0.0002851591,0.0008925875,0.0002952821,0.001111421,0.0002477374,0.0003962649,0.001881203],"category_scores_gemma":[0.001195562,0.0001392778,0.0001303706,0.001044142,0.0004133713,0.0004529102,0.0004071304,0.0003340629,0.0002529363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001008272,"about_ca_system_score_gemma":0.000501233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002358851,"about_ca_topic_score_gemma":0.004287078,"domain_scores_codex":[0.9997404,0.00005100324,0.00002147778,0.00005107313,0.00007289312,0.00006307074],"domain_scores_gemma":[0.9996762,0.00006897413,0.00009662036,0.00001229146,0.00006592061,0.00007993504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003059749,0.0001295239,0.5876769,0.000400203,0.000270228,0.004103319,0.0004071027,0.003773361,0.09254874,0.0135484,0.01063454,0.2834479],"study_design_scores_gemma":[0.0000462184,0.0005271401,0.9336421,0.0001006111,0.0002193091,0.009732842,0.0008160275,0.003199417,0.007729162,0.00854184,0.03540621,0.00003911247],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9359775,0.03531873,0.000701495,0.009488545,0.00008705301,0.00001411238,0.0007912601,0.00008651298,0.01753486],"genre_scores_gemma":[0.9948774,0.003742856,0.000164751,0.0004052738,0.00008429679,0.000003957006,0.000160333,0.00001064284,0.0005505645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002358851,"threshold_uncertainty_score":0.007315576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02790282534814936,"score_gpt":0.3666921568710767,"score_spread":0.3387893315229273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}