{"id":"W3132425762","doi":"10.26434/chemrxiv.13853345.v1","title":"Liquiritin from Glycirrhyza Glabra L (Fabaceae) - a Natural Derived Drug, as a Potential Inhibitor for SARS-CoV-2","year":2021,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Pharmacological Effects of Natural Compounds","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Social Sciences and Humanities Research Council; Social Sciences and Humanities Research Council of Canada","keywords":"Liquiritin; Virtual screening; Chemistry; Glycyrrhiza; Hydroxychloroquine; Pharmacology; Liquiritigenin; Traditional medicine; AutoDock; In silico; Drug discovery; Coronavirus disease 2019 (COVID-19); Medicine; Biochemistry; Chromatography; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007227233,0.0002280322,0.0003788974,0.0001753535,0.0001638219,0.0003075298,0.0002430604,0.0002373212,0.001502962],"category_scores_gemma":[0.00009306204,0.0001078401,0.0004809375,0.0001815359,0.00008902573,0.0002141247,0.000148852,0.0003524877,0.000234496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002508326,"about_ca_system_score_gemma":0.0001966295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002094353,"about_ca_topic_score_gemma":0.002247143,"domain_scores_codex":[0.9999692,0.000005069866,0.000001621833,0.000006376088,0.00001044151,0.000007177818],"domain_scores_gemma":[0.9999834,0.000004147445,0.000005587547,9.760615e-7,0.000002601853,0.000003245509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001112582,0.000354034,0.006456411,0.001423957,0.0001821184,0.0009827196,0.00008657314,0.05467562,0.903354,0.001153772,0.001206322,0.02901179],"study_design_scores_gemma":[0.0008120571,0.00469994,0.03271853,0.0001987078,0.0007620753,0.003171002,0.000589671,0.3060336,0.5959404,0.002213981,0.05274647,0.0001136623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842158,0.006874793,0.004889509,0.0002751481,0.00002178476,0.00002025372,0.0008698924,0.0001823176,0.002650508],"genre_scores_gemma":[0.9908907,0.002059731,0.004819645,0.00005058049,0.00000389227,0.000009779421,0.000942311,0.00001890315,0.001204452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002094353,"threshold_uncertainty_score":0.00502789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08606858116796676,"score_gpt":0.4256302445468831,"score_spread":0.3395616633789164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}