{"id":"W3132465430","doi":"10.1097/ccm.0000000000004842","title":"Sepsis Subclasses: A Framework for Development and Interpretation*","year":2021,"lang":"en","type":"article","venue":"Critical Care Medicine","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":173,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"NIHR Imperial Biomedical Research Centre; Genentech; National Heart, Lung, and Blood Institute; Defense Threat Reduction Agency; National Institutes of Health; Defense Advanced Research Projects Agency; Research Councils UK; National Institute of General Medical Sciences; National Institute for Health and Care Research; Wellcome Trust; Bristol-Myers Squibb; CSL Behring; Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Department of Defense; Sanofi; GlaxoSmithKline; Centers for Disease Control and Prevention; National Institute of Allergy and Infectious Diseases; Bayer","keywords":"Sepsis; Medicine; Intensive care medicine; Interpretation (philosophy); Clinical trial; Immunology; Computer science; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007855557,0.000139822,0.0003607986,0.00005360485,0.00008811764,0.00001587526,0.00002784205,0.00009245821,0.0003118644],"category_scores_gemma":[0.003640574,0.0001038901,0.00005714147,0.0001225242,0.0001545204,0.00002857897,0.00002915729,0.0001109554,0.000009468621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009696705,"about_ca_system_score_gemma":0.000149057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000037563,"about_ca_topic_score_gemma":0.000009570042,"domain_scores_codex":[0.998982,0.00002232665,0.0002489329,0.000315616,0.0002191592,0.0002119546],"domain_scores_gemma":[0.9977807,0.001279145,0.00001656067,0.000184975,0.000483997,0.0002546366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006291477,0.001342824,0.1396563,0.007161352,0.000814557,0.001719954,0.03566808,6.685254e-7,0.0009252722,0.3512829,0.01351065,0.4472883],"study_design_scores_gemma":[0.020417,0.007707444,0.2226955,0.01750365,0.006126888,0.001021728,0.154403,0.0006394559,0.09475426,0.04787361,0.4253006,0.001556892],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6899823,0.05942341,0.1020598,0.1381635,0.00144947,0.00127758,0.00003408167,0.0002049143,0.007404954],"genre_scores_gemma":[0.9429721,0.00007830071,0.05031462,0.006017899,0.0002285588,0.0001826888,0.0001069897,0.0000191601,0.00007965292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4457314,"threshold_uncertainty_score":0.435837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09479138859239584,"score_gpt":0.4235868370999685,"score_spread":0.3287954485075726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}