{"id":"W3132465430","doi":"10.1097/ccm.0000000000004842","title":"Sepsis Subclasses: A Framework for Development and Interpretation*","year":2021,"lang":"en","type":"article","venue":"Critical Care Medicine","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":173,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"NIHR Imperial Biomedical Research Centre; Genentech; National Heart, Lung, and Blood Institute; Defense Threat Reduction Agency; National Institutes of Health; Defense Advanced Research Projects Agency; Research Councils UK; National Institute of General Medical Sciences; National Institute for Health and Care Research; Wellcome Trust; Bristol-Myers Squibb; CSL Behring; Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Department of Defense; Sanofi; GlaxoSmithKline; Centers for Disease Control and Prevention; National Institute of Allergy and Infectious Diseases; Bayer","keywords":"Sepsis; Medicine; Intensive care medicine; Interpretation (philosophy); Clinical trial; Immunology; Computer science; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1817212,0.003005742,0.003397029,0.01704855,0.005094851,0.01804094,0.009224337,0.005064155,0.007419824],"category_scores_gemma":[0.2239051,0.002208222,0.006405878,0.01174116,0.02046891,0.02388545,0.01272353,0.01182791,0.002366024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.008472675,"about_ca_system_score_gemma":0.01986191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0126128,"about_ca_topic_score_gemma":0.007471622,"domain_scores_codex":[0.8883113,0.08421186,0.01271078,0.006325847,0.007309851,0.001130322],"domain_scores_gemma":[0.70253,0.2351227,0.01280087,0.01935311,0.02530436,0.004889034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00005908812,0.00005137368,0.001766969,0.0007155513,0.0001156285,0.0002164615,0.002904561,0.00121511,0.0001584426,0.9313421,0.01376391,0.04769066],"study_design_scores_gemma":[0.0000381111,0.00003167637,0.0004314081,0.0009814599,0.00007117768,0.0002148345,0.001002159,0.008854545,0.0001961582,0.9043039,0.08382729,0.00004727788],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.0009592077,0.003186993,0.9703926,0.01680952,0.0006344612,0.0009377445,0.0009569874,0.0008957796,0.005226656],"genre_scores_gemma":[0.01499485,0.001121704,0.9771264,0.002221183,0.0005530341,0.002071183,0.001087049,0.0002521035,0.0005724473],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.1817212,"threshold_uncertainty_score":0.961045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09479138859239584,"score_gpt":0.4235868370999685,"score_spread":0.3287954485075726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}