{"id":"W3132517371","doi":"10.3324/haematol.2020.261354","title":"The &lt;i&gt;EBF1-PDGFRB&lt;/i&gt; T681I mutation is highly resistant to imatinib and dasatinib &lt;i&gt;in vitro&lt;/i&gt; and detectable in clinical samples prior to treatment","year":2021,"lang":"en","type":"letter","venue":"Haematologica","topic":"Eosinophilic Disorders and Syndromes","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Cancer Institute; National Institutes of Health; Children’s Oncology Group; Frank A. Campini Foundation; American Lebanese Syrian Associated Charities; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Dasatinib; PDGFRB; In vitro; Imatinib; Cancer research; Mutation; Medicine; Molecular biology; Internal medicine; Pharmacology; Biology; Genetics; Gene; Myeloid leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004575952,0.0006457105,0.0006314146,0.0004511175,0.002070476,0.00141371,0.0007407043,0.01363568,0.008091429],"category_scores_gemma":[0.003289931,0.0004044146,0.0004655021,0.0004145103,0.001188325,0.001095679,0.0003884482,0.008207613,0.006247718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001989092,"about_ca_system_score_gemma":0.001182726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005623045,"about_ca_topic_score_gemma":0.007576882,"domain_scores_codex":[0.9994993,0.0001350559,0.00003958262,0.00008509953,0.0001128863,0.0001280832],"domain_scores_gemma":[0.9990492,0.0003997509,0.00006731161,0.00005688947,0.0001564132,0.0002704573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.000346717,0.0001378811,0.007236672,0.000092668,0.00003477175,0.2375033,0.0003369126,0.0003440542,0.002327803,0.005506824,0.7297392,0.0163932],"study_design_scores_gemma":[0.0002786758,0.0002765518,0.01039915,0.0003315256,0.00007346345,0.2399572,0.0009818481,0.002572875,0.002346988,0.01396015,0.7287287,0.00009294483],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.02184416,0.002794991,0.0004957403,0.9009035,0.01223591,0.00007640772,0.0004911334,0.0001499645,0.06100813],"genre_scores_gemma":[0.349691,0.007182109,0.002195633,0.5044978,0.03226687,0.000154561,0.0007178702,0.0001997799,0.1030944],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01363568,"threshold_uncertainty_score":0.0270685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03705287857448447,"score_gpt":0.3001651211904886,"score_spread":0.2631122426160041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}