{"id":"W3132523507","doi":"10.1126/sciimmunol.abb7221","title":"Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation","year":2021,"lang":"en","type":"article","venue":"Science Immunology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":175,"is_retracted":false,"has_abstract":true,"ca_institutions":"Artificial Intelligence in Medicine (Canada)","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Harvard Digestive Diseases Center, Harvard University; Horizon 2020 Framework Programme; AGA Research Foundation; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Richard and Susan Smith Family Foundation; Directorate-General for Research and Innovation; Searle Scholars Program; Damon Runyon Cancer Research Foundation; Alfred P. Sloan Foundation; European Commission; National Institute of Diabetes and Digestive and Kidney Diseases; Bill and Melinda Gates Foundation; New York Stem Cell Foundation; Food Allergy Science Initiative","keywords":"Inflammation; Phenotype; Immunology; Biology; Mast cell; Allergic inflammation; Mast (botany); Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001166622,0.0001792608,0.0001305579,0.0002872465,0.0001558668,0.0002452722,0.00005314107,0.0002052868,0.001679335],"category_scores_gemma":[0.0001217439,0.0001322194,0.0001823098,0.000157835,0.0001582092,0.0001607955,0.0001511483,0.0002820171,0.0004074609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000977578,"about_ca_system_score_gemma":0.00006580589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004346711,"about_ca_topic_score_gemma":0.0008202407,"domain_scores_codex":[0.9999027,0.00002283021,0.000005866948,0.00002045933,0.00002059861,0.00002746312],"domain_scores_gemma":[0.999933,0.00001420796,0.0000125439,0.00001198304,0.000009265428,0.00001902254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002143788,0.00001227979,0.002134597,0.0000140301,0.000003070878,0.0001992415,0.00007009692,0.00001707801,0.9961805,0.00003161824,0.00003092018,0.001092142],"study_design_scores_gemma":[0.00005282399,0.001181332,0.3342765,0.00001210019,0.00004076954,0.005406742,0.0005611888,0.000694815,0.6528053,0.0002118569,0.004734584,0.00002189303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968352,0.0007993769,0.0007370525,0.00003021987,0.00001911404,0.00002338036,0.0002376011,0.00002277375,0.001295239],"genre_scores_gemma":[0.997635,0.0002800112,0.0004430578,0.00003622516,0.00001523468,0.0000319458,0.0002806793,0.000006228383,0.001271532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001679335,"threshold_uncertainty_score":0.005617917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007585160069633365,"score_gpt":0.2234582249060579,"score_spread":0.2158730648364245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}