{"id":"W3132523507","doi":"10.1126/sciimmunol.abb7221","title":"Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation","year":2021,"lang":"en","type":"article","venue":"Science Immunology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":175,"is_retracted":false,"has_abstract":true,"ca_institutions":"Artificial Intelligence in Medicine (Canada)","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Harvard Digestive Diseases Center, Harvard University; Horizon 2020 Framework Programme; AGA Research Foundation; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Richard and Susan Smith Family Foundation; Directorate-General for Research and Innovation; Searle Scholars Program; Damon Runyon Cancer Research Foundation; Alfred P. Sloan Foundation; European Commission; National Institute of Diabetes and Digestive and Kidney Diseases; Bill and Melinda Gates Foundation; New York Stem Cell Foundation; Food Allergy Science Initiative","keywords":"Inflammation; Phenotype; Immunology; Biology; Mast cell; Allergic inflammation; Mast (botany); Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002330065,0.0001744818,0.0002399719,0.0001731534,0.0009295506,0.00007446815,0.0002774546,0.0001652037,0.00116753],"category_scores_gemma":[0.00009826271,0.0001637797,0.00003098297,0.000438155,0.001332697,0.0003152776,0.0003054148,0.0002248004,0.0003477041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000619292,"about_ca_system_score_gemma":0.0001965229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004115642,"about_ca_topic_score_gemma":0.0001205374,"domain_scores_codex":[0.9985768,0.0001118953,0.0003243278,0.0004662072,0.00006049945,0.0004603087],"domain_scores_gemma":[0.9991379,0.00003205541,0.0001575505,0.0003486567,0.0002940655,0.00002977757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003327401,0.00002173069,0.001381695,0.00002744581,0.00002937178,0.0000112585,0.0006077126,0.00001399369,0.991767,0.003067619,0.00003228986,0.003006625],"study_design_scores_gemma":[0.0006432389,0.0001245338,0.06295687,0.00002929448,0.00002002121,0.0001011336,0.000288729,0.00002350445,0.9275352,0.0002219481,0.007829885,0.0002255868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947345,0.0008123186,0.00001803499,0.0003819674,0.0008207451,0.0001576411,0.000008747304,0.00006882883,0.002997226],"genre_scores_gemma":[0.9932,0.00007074718,0.000120633,0.00001849437,0.00006892071,0.00001250171,0.00007093443,0.00001184723,0.006425946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06423173,"threshold_uncertainty_score":0.9997455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007585160069633365,"score_gpt":0.2234582249060579,"score_spread":0.2158730648364245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}