{"id":"W3132541859","doi":"10.3390/metabo11020109","title":"Early Noninvasive Metabolic Biomarkers of Mutant IDH Inhibition in Glioma","year":2021,"lang":"en","type":"article","venue":"Metabolites","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; University of California, San Francisco; National Institutes of Health","keywords":"Isocitrate dehydrogenase; Glioma; Mutant; Glutamine; IDH1; Cancer research; In vivo; Biology; Glutamate receptor; Chemistry; Biochemistry; Enzyme; Gene; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001733056,0.0001825446,0.0006050199,0.0003788694,0.00003177141,0.00001943944,0.00003277421,0.00008144719,0.0002332644],"category_scores_gemma":[0.0002339069,0.0001514707,0.0002108369,0.001077976,0.00007011778,0.000102754,0.00004461911,0.00008514187,0.00004155688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002881138,"about_ca_system_score_gemma":0.000102587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002729981,"about_ca_topic_score_gemma":0.00006085601,"domain_scores_codex":[0.9985922,0.00009509763,0.0004240185,0.0003171136,0.000296545,0.0002750111],"domain_scores_gemma":[0.9991086,0.0001095605,0.000113695,0.0003325638,0.0002165698,0.0001190203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008876681,0.00109959,0.1527793,0.00006989815,0.0004355377,0.003041138,0.0004755231,0.000002635363,0.8330688,0.0049609,0.00004681831,0.003930996],"study_design_scores_gemma":[0.002087538,0.00005374414,0.3480935,0.00009845932,0.0002464842,0.0001784558,0.0001641384,0.000007526711,0.6475189,0.0002520157,0.00121726,0.00008196287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769309,0.02069892,0.000007592753,0.0005371523,0.0001204255,0.0002768422,0.00004909877,0.0000258918,0.001353175],"genre_scores_gemma":[0.9977934,0.0005994476,0.001259547,0.0001069201,0.00005876396,0.00006402421,0.00006605539,0.00002191285,0.00002994264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1953141,"threshold_uncertainty_score":0.6176796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01435675777904402,"score_gpt":0.2575651677811056,"score_spread":0.2432084100020615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}