{"id":"W3132541859","doi":"10.3390/metabo11020109","title":"Early Noninvasive Metabolic Biomarkers of Mutant IDH Inhibition in Glioma","year":2021,"lang":"en","type":"article","venue":"Metabolites","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; University of California, San Francisco; National Institutes of Health","keywords":"Isocitrate dehydrogenase; Glioma; Mutant; Glutamine; IDH1; Cancer research; In vivo; Biology; Glutamate receptor; Chemistry; Biochemistry; Enzyme; Gene; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001178607,0.0003948162,0.0002515657,0.0002805655,0.00006679737,0.0002078377,0.0001555943,0.0003150048,0.0004472481],"category_scores_gemma":[0.0001285307,0.0001350798,0.000119964,0.0001264622,0.0001537155,0.0002093598,0.0001663614,0.0003515371,0.0001241946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001723586,"about_ca_system_score_gemma":0.0001243629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004685826,"about_ca_topic_score_gemma":0.000932935,"domain_scores_codex":[0.9999291,0.00001637361,0.000003251262,0.00001264043,0.00002277784,0.00001597994],"domain_scores_gemma":[0.999939,0.00001006562,0.00002524776,0.000004086643,0.000009066201,0.00001250142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001631566,0.00001328153,0.0002672258,0.00002616759,0.000005317988,0.00003530502,0.00000827472,0.00007289984,0.9977875,0.00001789937,0.00002418208,0.001578735],"study_design_scores_gemma":[0.00001826443,0.0008640205,0.0144773,0.000006254352,0.00003540163,0.0004631018,0.00004694904,0.001265332,0.9819236,0.0000684771,0.0008216591,0.000009581144],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895343,0.003008849,0.006187518,0.00008592614,0.00001930883,0.00003109045,0.0002318195,0.0001312418,0.0007697939],"genre_scores_gemma":[0.9901917,0.002003939,0.00612985,0.00008672589,0.00001409736,0.00003902427,0.0003625025,0.00002222181,0.001150069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004685826,"threshold_uncertainty_score":0.001496196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01435675777904402,"score_gpt":0.2575651677811056,"score_spread":0.2432084100020615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}