{"id":"W3132628957","doi":"10.1016/j.exphem.2020.09.077","title":"3060 – DOWNREGULATED STAUFEN1 COMPROMISES HEMATOPOIETIC STEM CELL ACTIVITY IN VIVO AND ELICITS EXPRESSION SIGNATURES CHARACTERISTIC OF CLINICAL ANEMIAS","year":2020,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of Toronto; McMaster University; BC Children's Hospital","funders":"","keywords":"Biology; RNA-binding protein; Haematopoiesis; Cell biology; Transcriptome; Hematopoietic stem cell; Stem cell; Erythropoiesis; RNA; Gene expression; Genetics; Gene; Anemia; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001332503,0.0001825303,0.0004968005,0.0000397527,0.00004310331,0.00001075417,0.0001669726,0.0002597885,0.0000450197],"category_scores_gemma":[0.00003361381,0.0001649244,0.00007566276,0.00007654094,0.0001906633,0.00000838829,0.0002531657,0.0001958976,0.000003111538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008078839,"about_ca_system_score_gemma":0.00004801017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001881773,"about_ca_topic_score_gemma":0.000003418279,"domain_scores_codex":[0.9984757,0.0002158122,0.0004280207,0.0004610879,0.0001371952,0.0002821318],"domain_scores_gemma":[0.9993386,0.00006458708,0.0001623141,0.0002070888,0.00002936309,0.0001980653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008592808,0.000265011,0.004378764,0.0001348527,0.00001374121,0.00003929122,0.0002071704,0.00000363415,0.9934855,0.00006626414,0.0003577402,0.0001887633],"study_design_scores_gemma":[0.001383128,0.0006505951,0.002210344,0.00004219779,0.000003604667,0.00002156042,0.0003998636,0.0003589637,0.9946544,0.000002961433,0.0001198912,0.0001525071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956117,0.003710839,0.00005482406,0.00009684578,0.00005165188,0.0002816154,0.00001620751,0.00001262366,0.0001636968],"genre_scores_gemma":[0.9994465,0.0000827908,0.0001404825,0.0001245415,0.00004321454,0.00002140044,0.00001619068,0.00001933759,0.0001055718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003834774,"threshold_uncertainty_score":0.6725423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02856562515636384,"score_gpt":0.3307235227710464,"score_spread":0.3021578976146826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}