{"id":"W3132628957","doi":"10.1016/j.exphem.2020.09.077","title":"3060 – DOWNREGULATED STAUFEN1 COMPROMISES HEMATOPOIETIC STEM CELL ACTIVITY IN VIVO AND ELICITS EXPRESSION SIGNATURES CHARACTERISTIC OF CLINICAL ANEMIAS","year":2020,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of Toronto; McMaster University; BC Children's Hospital","funders":"","keywords":"Biology; RNA-binding protein; Haematopoiesis; Cell biology; Transcriptome; Hematopoietic stem cell; Stem cell; Erythropoiesis; RNA; Gene expression; Genetics; Gene; Anemia; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002099487,0.0003833645,0.0002910591,0.0003642249,0.0002069518,0.0003268783,0.0002499757,0.0005567523,0.004609115],"category_scores_gemma":[0.0001954174,0.0001609964,0.0002296713,0.0002656816,0.0005439796,0.0001418465,0.0001766351,0.00086063,0.001108583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003523079,"about_ca_system_score_gemma":0.000281184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008470349,"about_ca_topic_score_gemma":0.001472732,"domain_scores_codex":[0.9996698,0.00006916167,0.00003290533,0.0000587699,0.00009509394,0.00007428772],"domain_scores_gemma":[0.9998135,0.00004593852,0.00004519449,0.00002037709,0.00001046416,0.00006459271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002347856,0.0000471583,0.0001525932,0.00001837384,0.000008218347,0.0001232813,0.00001048991,0.0001147072,0.998151,0.0001797535,0.0001691355,0.0007904737],"study_design_scores_gemma":[0.00004851988,0.0004522287,0.005787327,0.000006678911,0.00002018952,0.0009157445,0.00006861704,0.002157391,0.9859375,0.0001410248,0.004455872,0.000008790019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926339,0.0007980354,0.001922096,0.000365162,0.0001098527,0.00003980857,0.001239708,0.0001888287,0.002702719],"genre_scores_gemma":[0.9929376,0.0002416851,0.001135026,0.0001296928,0.00001721556,0.0000302786,0.0009816043,0.0000358471,0.004491104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004609115,"threshold_uncertainty_score":0.01541901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02856562515636384,"score_gpt":0.3307235227710464,"score_spread":0.3021578976146826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}